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Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone.
du Toit T, Bloem LM, Quanson JL, Ehlers R, Serafin AM, Swart AC. du Toit T, et al. Among authors: swart ac. J Steroid Biochem Mol Biol. 2017 Feb;166:54-67. doi: 10.1016/j.jsbmb.2016.06.009. Epub 2016 Jun 21. J Steroid Biochem Mol Biol. 2017. PMID: 27345701
A high-throughput UPC2-MS/MS method for the separation and quantification of C19 and C21 steroids and their C11-oxy steroid metabolites in the classical, alternative, backdoor and 11OHA4 steroid pathways.
du Toit T, Stander MA, Swart AC. du Toit T, et al. Among authors: swart ac. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:71-81. doi: 10.1016/j.jchromb.2018.02.023. Epub 2018 Feb 20. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29482121
11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro.
Gent R, du Toit T, Swart AC. Gent R, et al. Among authors: swart ac. J Steroid Biochem Mol Biol. 2019 Jul;191:105369. doi: 10.1016/j.jsbmb.2019.04.018. Epub 2019 Apr 27. J Steroid Biochem Mol Biol. 2019. PMID: 31039398
84 results