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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.
Nat Commun. 2023 Jun 23;14(1):3742. doi: 10.1038/s41467-023-39241-7.
Nat Commun. 2023.
PMID: 37353488
Free PMC article.
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
Joshi S, Gomes ED, Wang T, Corben A, Taldone T, Gandu S, Xu C, Sharma S, Buddaseth S, Yan P, Chan LYL, Gokce A, Rajasekhar VK, Shrestha L, Panchal P, Almodovar J, Digwal CS, Rodina A, Merugu S, Pillarsetty N, Miclea V, Peter RI, Wang W, Ginsberg SD, Tang L, Mattar M, de Stanchina E, Yu KH, Lowery M, Grbovic-Huezo O, O'Reilly EM, Janjigian Y, Healey JH, Jarnagin WR, Allen PJ, Sander C, Erdjument-Bromage H, Neubert TA, Leach SD, Chiosis G.
Joshi S, et al. Among authors: merugu s.
Commun Biol. 2021 Nov 25;4(1):1333. doi: 10.1038/s42003-021-02842-3.
Commun Biol. 2021.
PMID: 34824367
Free PMC article.
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Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies.
Merugu S, Sharma S, Kaner J, Digwal C, Sugita M, Joshi S, Taldone T, Guzman ML, Chiosis G.
Merugu S, et al.
Methods Enzymol. 2020;639:289-311. doi: 10.1016/bs.mie.2020.04.057. Epub 2020 May 10.
Methods Enzymol. 2020.
PMID: 32475406
Free PMC article.
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Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers.
Merugu S, Chen L, Gavens E, Gabra H, Brougham M, Makin G, Ng A, Murphy D, Gabriel AS, Robinson ML, Wright JH, Burchill SA, Humphreys A, Bown N, Jamieson D, Tweddle DA.
Merugu S, et al.
Clin Cancer Res. 2020 Jan 1;26(1):122-134. doi: 10.1158/1078-0432.CCR-19-0656. Epub 2019 Nov 25.
Clin Cancer Res. 2020.
PMID: 31767563
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Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia.
Sugita M, Wilkes DC, Bareja R, Eng KW, Nataraj S, Jimenez-Flores RA, Yan L, De Leon JP, Croyle JA, Kaner J, Merugu S, Sharma S, MacDonald TY, Noorzad Z, Panchal P, Pancirer D, Cheng S, Xiang JZ, Olson L, Van Besien K, Rickman DS, Mathew S, Tam W, Rubin MA, Beltran H, Sboner A, Hassane DC, Chiosis G, Elemento O, Roboz GJ, Mosquera JM, Guzman ML.
Sugita M, et al. Among authors: merugu s.
NPJ Precis Oncol. 2021 May 26;5(1):44. doi: 10.1038/s41698-021-00183-2.
NPJ Precis Oncol. 2021.
PMID: 34040147
Free PMC article.
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