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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
Gunasekaran K, Pentony M, Shen M, Garrett L, Forte C, Woodward A, Ng SB, Born T, Retter M, Manchulenko K, Sweet H, Foltz IN, Wittekind M, Yan W. Gunasekaran K, et al. Among authors: sweet h. J Biol Chem. 2010 Jun 18;285(25):19637-46. doi: 10.1074/jbc.M110.117382. Epub 2010 Apr 16. J Biol Chem. 2010. PMID: 20400508 Free PMC article.
Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.
Liu Z, Gunasekaran K, Wang W, Razinkov V, Sekirov L, Leng E, Sweet H, Foltz I, Howard M, Rousseau AM, Kozlosky C, Fanslow W, Yan W. Liu Z, et al. Among authors: sweet h. J Biol Chem. 2014 Feb 7;289(6):3571-90. doi: 10.1074/jbc.M113.513366. Epub 2013 Dec 5. J Biol Chem. 2014. PMID: 24311787 Free PMC article.
Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab.
Jassem S, Wang W, Sweet H, Manoukian R, Chow V, Kanakaraj P, Hutterer KM, Kuhns S, Foltz IN, Chen Q, Ferbas J, McBride HJ. Jassem S, et al. Among authors: sweet h. Pharm Res. 2019 Nov 6;36(12):177. doi: 10.1007/s11095-019-2702-8. Pharm Res. 2019. PMID: 31696314 Free PMC article.
76 results