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A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi-Carter R, Westerberg G, Marsh JL. Smith MR, et al. Among authors: syed a. Hum Mol Genet. 2014 Jun 1;23(11):2995-3007. doi: 10.1093/hmg/ddu010. Epub 2014 Jan 16. Hum Mol Genet. 2014. PMID: 24436303 Free PMC article.
Nonmammalian Models of Huntington's Disease.
Chongtham A, Barbaro B, Filip T, Syed A, Huang W, Smith MR, Marsh JL. Chongtham A, et al. Among authors: syed a. Methods Mol Biol. 2018;1780:75-96. doi: 10.1007/978-1-4939-7825-0_5. Methods Mol Biol. 2018. PMID: 29856015
Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila.
Syed A, Lukacsovich T, Pomeroy M, Bardwell AJ, Decker GT, Waymire KG, Purcell J, Huang W, Gui J, Padilla EM, Park C, Paul A, Pham TBT, Rodriguez Y, Wei S, Worthge S, Zebarjedi R, Zhang B, Bardwell L, Marsh JL, MacGregor GR. Syed A, et al. Dev Biol. 2019 Jan 1;445(1):37-53. doi: 10.1016/j.ydbio.2018.10.016. Epub 2018 Oct 25. Dev Biol. 2019. PMID: 30539716 Free PMC article.
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.
Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, Chen Y, Sharma S, Sangrey GR, Darnell SB, Plasterer H, Sadri-Vakili G, Gottesfeld JM, Thompson LM, Rusche JR, Marsh JL, Thomas EA. Jia H, et al. Among authors: syed a. Neurobiol Dis. 2012 May;46(2):351-61. doi: 10.1016/j.nbd.2012.01.016. Neurobiol Dis. 2012. PMID: 22590724 Free PMC article.
A unique DNA binding domain converts T-cell factors into strong Wnt effectors.
Atcha FA, Syed A, Wu B, Hoverter NP, Yokoyama NN, Ting JH, Munguia JE, Mangalam HJ, Marsh JL, Waterman ML. Atcha FA, et al. Among authors: syed a. Mol Cell Biol. 2007 Dec;27(23):8352-63. doi: 10.1128/MCB.02132-06. Epub 2007 Sep 24. Mol Cell Biol. 2007. PMID: 17893322 Free PMC article.
1,465 results