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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1957 1
1964 2
1966 1
1967 1
1968 1
1969 1
1970 2
1971 5
1972 3
1973 15
1974 7
1975 108
1976 107
1977 112
1978 134
1979 133
1980 139
1981 203
1982 206
1983 231
1984 316
1985 247
1986 296
1987 310
1988 347
1989 318
1990 352
1991 359
1992 388
1993 427
1994 394
1995 426
1996 435
1997 464
1998 507
1999 515
2000 574
2001 504
2002 635
2003 617
2004 651
2005 707
2006 703
2007 721
2008 800
2009 817
2010 875
2011 1005
2012 1094
2013 1052
2014 1159
2015 1167
2016 896
2017 639
2018 904
2019 954
2020 972
2021 1033
2022 937
2023 728
2024 94

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25,449 results

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Page 1
The role of CD8+ T-cell clones in immune thrombocytopenia.
Malik A, Sayed AA, Han P, Tan MMH, Watt E, Constantinescu-Bercu A, Cocker ATH, Khoder A, Saputil RC, Thorley E, Teklemichael A, Ding Y, Hart ACJ, Zhang H, Mitchell WA, Imami N, Crawley JTB, Salles-Crawley II, Bussel JB, Zehnder JL, Adams S, Zhang BM, Cooper N. Malik A, et al. Among authors: cooper n. Blood. 2023 May 18;141(20):2417-2429. doi: 10.1182/blood.2022018380. Blood. 2023. PMID: 36749920 Free PMC article.
In this study, we use a multidimensional approach to explore the role of cytotoxic CD8+ T cells in ITP. We characterized patients with ITP and compared them with age-matched controls using immunophenotyping, next-generation sequencing of T-cell receptor (TCR) genes, …
In this study, we use a multidimensional approach to explore the role of cytotoxic CD8+ T cells in ITP. We characterized patients wit …
An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF. Cooper ML, et al. Leukemia. 2018 Sep;32(9):1970-1983. doi: 10.1038/s41375-018-0065-5. Epub 2018 Feb 20. Leukemia. 2018. PMID: 29483708 Free PMC article.
The shared expression of target antigens between chimeric antigen receptor (CAR) T cells and malignant T cells has limited the development of CAR-T because of unintended CAR-T fratricide and an inability to harvest sufficient autologous T cells. …
The shared expression of target antigens between chimeric antigen receptor (CAR) T cells and malignant T cells has limited the …
An "off-the-shelf" CD2 universal CAR-T therapy for T-cell malignancies.
Xiang J, Devenport JM, Carter AJ, Staser KW, Kim MY, O' Neal J, Ritchey JK, Rettig MP, Gao F, Rettig G, Turk R, Lee BH, Cooper ML, DiPersio JF. Xiang J, et al. Among authors: cooper ml. Leukemia. 2023 Dec;37(12):2448-2456. doi: 10.1038/s41375-023-02039-z. Epub 2023 Oct 5. Leukemia. 2023. PMID: 37798328 Free PMC article.
To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic "universal" CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to prevent fratricide, and the T-cell receptor is removed to prevent GvHD. UCART …
To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic "universal" CD2-targeting CAR-T …
Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.
Hurton LV, Singh H, Najjar AM, Switzer KC, Mi T, Maiti S, Olivares S, Rabinovich B, Huls H, Forget MA, Datar V, Kebriaei P, Lee DA, Champlin RE, Cooper LJ. Hurton LV, et al. Among authors: cooper lj. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7788-E7797. doi: 10.1073/pnas.1610544113. Epub 2016 Nov 14. Proc Natl Acad Sci U S A. 2016. PMID: 27849617 Free PMC article.
T-memory stem cells (T(SCM)) retain superior potential for long-lived persistence, but challenges exist in manufacturing this T-cell subset because they are rare among circulating lymphocytes. We report a clinically relevant approach to generating CAR(+) T …
T-memory stem cells (T(SCM)) retain superior potential for long-lived persistence, but challenges exist in manufacturing this …
Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer.
Tchou J, Zhao Y, Levine BL, Zhang PJ, Davis MM, Melenhorst JJ, Kulikovskaya I, Brennan AL, Liu X, Lacey SF, Posey AD Jr, Williams AD, So A, Conejo-Garcia JR, Plesa G, Young RM, McGettigan S, Campbell J, Pierce RH, Matro JM, DeMichele AM, Clark AS, Cooper LJ, Schuchter LM, Vonderheide RH, June CH. Tchou J, et al. Among authors: cooper lj. Cancer Immunol Res. 2017 Dec;5(12):1152-1161. doi: 10.1158/2326-6066.CIR-17-0189. Epub 2017 Nov 6. Cancer Immunol Res. 2017. PMID: 29109077 Free PMC article. Clinical Trial.
Chimeric antigen receptors (CAR) are synthetic molecules that provide new specificities to T cells. Although successful in treatment of hematologic malignancies, CAR T cells are ineffective for solid tumors to date. ...We conclude that intratumoral injections of mRN …
Chimeric antigen receptors (CAR) are synthetic molecules that provide new specificities to T cells. Although successful in treatment …
Chimeric antigen receptor T cells (CAR-T) for the treatment of T-cell malignancies.
Cooper ML, DiPersio JF. Cooper ML, et al. Best Pract Res Clin Haematol. 2019 Dec;32(4):101097. doi: 10.1016/j.beha.2019.101097. Epub 2019 Oct 18. Best Pract Res Clin Haematol. 2019. PMID: 31779968 Review.
T-ALL is a heterogeneous disease, but it has universal overexpression of CD7 as well as several other T-cell markers, such as CD2 and CD5. ...The challenges encountered and progress made in developing a novel fratricide-resistant "off-the-shelf" CAR-T (or UCA …
T-ALL is a heterogeneous disease, but it has universal overexpression of CD7 as well as several other T-cell markers, such as …
Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations.
Borna Š, Lee E, Nideffer J, Ramachandran A, Wang B, Baker J, Mavers M, Lakshmanan U, Narula M, Garrett AK, Schulze J, Olek S, Marois L, Gernez Y, Bhatia M, Chong HJ, Walter J, Kitcharoensakkul M, Lang A, Cooper MA, Bertaina A, Roncarolo MG, Meffre E, Bacchetta R. Borna Š, et al. Among authors: cooper ma. Sci Transl Med. 2023 Dec 20;15(727):eadg6822. doi: 10.1126/scitranslmed.adg6822. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117899
We found that patients with IPEX, unlike patients with APECED, have expanded autoreactive T cells originating from both autoreactive effector T cells (T(effs)) and T(regs). ...Functional experiments with CRISPR-Cas9-mediated FOXP3 knockout T(reg …
We found that patients with IPEX, unlike patients with APECED, have expanded autoreactive T cells originating from both autoreactive …
Steering CAR T cells to distinguish friend from foe.
Caruso HG, Heimberger AB, Cooper LJN. Caruso HG, et al. Among authors: cooper ljn. Oncoimmunology. 2018 Aug 6;8(10):e1271857. doi: 10.1080/2162402X.2016.1271857. eCollection 2019. Oncoimmunology. 2018. PMID: 31646067 Free PMC article. Review.
Bioengineering approaches include: (i) targeting CAR(+) T cells to the tumor site, (ii) limiting CAR(+) T-cell persistence, and (iii) restricting CAR activation. We review and evaluate strategies to engineer CAR(+) T cells to reduce the potential of on-target …
Bioengineering approaches include: (i) targeting CAR(+) T cells to the tumor site, (ii) limiting CAR(+) T-cell persistence, an …
Immunopathogenesis of psoriasis.
Lee MR, Cooper AJ. Lee MR, et al. Among authors: cooper aj. Australas J Dermatol. 2006 Aug;47(3):151-9. doi: 10.1111/j.1440-0960.2006.00262.x. Australas J Dermatol. 2006. PMID: 16866993 Review.
This paper reviews the pathogenesis of psoriasis, in particular, the immunological cascade in psoriasis. Psoriasis is an immune-mediated skin disease where the T cell plays a pivotal role in the pathogenesis of the disease. The critical steps involved in the pathogenesis i …
This paper reviews the pathogenesis of psoriasis, in particular, the immunological cascade in psoriasis. Psoriasis is an immune-mediated ski …
Evolution of Alternative Adaptive Immune Systems in Vertebrates.
Boehm T, Hirano M, Holland SJ, Das S, Schorpp M, Cooper MD. Boehm T, et al. Among authors: cooper md. Annu Rev Immunol. 2018 Apr 26;36:19-42. doi: 10.1146/annurev-immunol-042617-053028. Epub 2017 Nov 16. Annu Rev Immunol. 2018. PMID: 29144837 Review.
Adaptive immunity in jawless fishes is based on antigen recognition by three types of variable lymphocyte receptors (VLRs) composed of variable leucine-rich repeats, which are differentially expressed by two T-like lymphocyte lineages and one B-like lymphocyte lineage. The …
Adaptive immunity in jawless fishes is based on antigen recognition by three types of variable lymphocyte receptors (VLRs) composed of varia …
25,449 results
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