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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
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1974 1
1975 5
1976 12
1977 12
1978 9
1979 15
1980 14
1981 14
1982 21
1983 20
1984 21
1985 13
1986 19
1987 15
1988 17
1989 18
1990 29
1991 35
1992 38
1993 36
1994 69
1995 63
1996 60
1997 74
1998 73
1999 109
2000 93
2001 103
2002 142
2003 152
2004 200
2005 251
2006 280
2007 390
2008 413
2009 457
2010 492
2011 590
2012 680
2013 702
2014 779
2015 844
2016 544
2017 397
2018 580
2019 630
2020 723
2021 768
2022 765
2023 552
2024 76

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10,885 results

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Page 1
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Yang X, Garner LI, Zvyagin IV, Paley MA, Komech EA, Jude KM, Zhao X, Fernandes RA, Hassman LM, Paley GL, Savvides CS, Brackenridge S, Quastel MN, Chudakov DM, Bowness P, Yokoyama WM, McMichael AJ, Gillespie GM, Garcia KC. Yang X, et al. Among authors: fernandes ra. Nature. 2022 Dec;612(7941):771-777. doi: 10.1038/s41586-022-05501-7. Epub 2022 Dec 7. Nature. 2022. PMID: 36477533 Free PMC article.
How HLA-B*27 facilitates disease remains unknown, but one possible mechanism could involve presentation of pathogenic peptides to CD8(+) T cells. Here we isolated orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-comple …
How HLA-B*27 facilitates disease remains unknown, but one possible mechanism could involve presentation of pathogenic peptides to CD8(+) …
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.
Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC. Gee MH, et al. Among authors: fernandes ra. Cell. 2018 Jan 25;172(3):549-563.e16. doi: 10.1016/j.cell.2017.11.043. Epub 2017 Dec 21. Cell. 2018. PMID: 29275860 Free PMC article.
The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" …
The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TI …
Immune receptor inhibition through enforced phosphatase recruitment.
Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC. Fernandes RA, et al. Nature. 2020 Oct;586(7831):779-784. doi: 10.1038/s41586-020-2851-2. Epub 2020 Oct 21. Nature. 2020. PMID: 33087934 Free PMC article.
As an example, we found that tonic signalling by the programmed cell death-1 receptor (PD-1) results in residual suppression of T cell activation, but is not inhibited by ligand-antagonist antibodies. ...We also show that the RIPR strategy extends to other immune-receptor …
As an example, we found that tonic signalling by the programmed cell death-1 receptor (PD-1) results in residual suppression of T cel …
Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC.
Sušac L, Vuong MT, Thomas C, von Bülow S, O'Brien-Ball C, Santos AM, Fernandes RA, Hummer G, Tampé R, Davis SJ. Sušac L, et al. Among authors: fernandes ra. Cell. 2022 Aug 18;185(17):3201-3213.e19. doi: 10.1016/j.cell.2022.07.010. Cell. 2022. PMID: 35985289 Free PMC article.
The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. ...The geometry of the pMHC/TCR complex suggests that efficient TCR scanning of pMHC requires accurate pre-positioning of T cell and antigen-pr …
The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. ...The geo …
Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity.
Vicente MM, Alves I, Fernandes Â, Dias AM, Santos-Pereira B, Pérez-Anton E, Santos S, Yang T, Correia A, Münster-Kühnel A, Almeida ARM, Ravens S, Rabinovich GA, Vilanova M, Sousa AE, Pinho SS. Vicente MM, et al. Among authors: fernandes a. Cell Mol Immunol. 2023 Aug;20(8):955-968. doi: 10.1038/s41423-023-01052-7. Epub 2023 Jun 21. Cell Mol Immunol. 2023. PMID: 37344746 Free PMC article.
T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. ...Here, we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes, as well as dy …
T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigen …
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC. Sibener LV, et al. Among authors: fernandes ra. Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017. Cell. 2018. PMID: 30053426 Free PMC article.
We find high-affinity, yet non-stimulatory, interactions occur with high frequency in the human T cell repertoire. Here, we studied human TCRs that are refractory to activation by pMHC ligands despite robust binding. ...
We find high-affinity, yet non-stimulatory, interactions occur with high frequency in the human T cell repertoire. Here, we studied h …
Opposing T cell responses in experimental autoimmune encephalomyelitis.
Saligrama N, Zhao F, Sikora MJ, Serratelli WS, Fernandes RA, Louis DM, Yao W, Ji X, Idoyaga J, Mahajan VB, Steinmetz LM, Chien YH, Hauser SL, Oksenberg JR, Garcia KC, Davis MM. Saligrama N, et al. Among authors: fernandes ra. Nature. 2019 Aug;572(7770):481-487. doi: 10.1038/s41586-019-1467-x. Epub 2019 Aug 7. Nature. 2019. PMID: 31391585 Free PMC article.
We also find major expansions of CD8(+) T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4(+) T cells are specific for the inducing myelin peptide MOG(35-55). ...These results suggest that the induction of au …
We also find major expansions of CD8(+) T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that mo …
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.
Acúrcio RC, Pozzi S, Carreira B, Pojo M, Gómez-Cebrián N, Casimiro S, Fernandes A, Barateiro A, Farricha V, Brito J, Leandro AP, Salvador JAR, Graça L, Puchades-Carrasco L, Costa L, Satchi-Fainaro R, Guedes RC, Florindo HF. Acúrcio RC, et al. Among authors: fernandes a. J Immunother Cancer. 2022 Jul;10(7):e004695. doi: 10.1136/jitc-2022-004695. J Immunother Cancer. 2022. PMID: 35863821 Free PMC article.
Unlike these biological compounds, our newly-identified small molecules enabled an extensive infiltration of T lymphocytes into three-dimensional solid tumor models, and the recruitment of cytotoxic T lymphocytes to the tumor microenvironment in vivo, unveiling a un …
Unlike these biological compounds, our newly-identified small molecules enabled an extensive infiltration of T lymphocytes into three …
Engineered tumor-specific T cells using immunostimulatory photothermal nanoparticles.
Sweeney EE, Sekhri P, Telaraja D, Chen J, Chin SJ, Chiappinelli KB, Sanchez CE, Bollard CM, Cruz CRY, Fernandes R. Sweeney EE, et al. Among authors: fernandes r. Cytotherapy. 2023 Jul;25(7):718-727. doi: 10.1016/j.jcyt.2023.03.014. Cytotherapy. 2023. PMID: 37278683 Free PMC article.
In contrast to existing chimeric antigen receptor (CAR) T cell and/or antigen-specific T cell approaches, which require known targets, and responsive to the need for targeting a broad repertoire of antigens in solid tumors, we describe the first use of immunostimula …
In contrast to existing chimeric antigen receptor (CAR) T cell and/or antigen-specific T cell approaches, which require known …
TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways.
Chan W, Cao YM, Zhao X, Schrom EC, Jia D, Song J, Sibener LV, Dong S, Fernandes RA, Bradfield CJ, Smelkinson M, Kabat J, Hor JL, Altan-Bonnet G, Garcia KC, Germain RN. Chan W, et al. Among authors: fernandes ra. J Exp Med. 2023 Dec 4;220(12):e20231242. doi: 10.1084/jem.20231242. Epub 2023 Oct 5. J Exp Med. 2023. PMID: 37796477 Free PMC article.
These findings help resolve discrepancies in existing data about the site(s) of PD-1 inhibition in T cells while emphasizing the importance of neoantigen potency in controlling the effects of checkpoint therapy....
These findings help resolve discrepancies in existing data about the site(s) of PD-1 inhibition in T cells while emphasizing the impo …
10,885 results
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