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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1967 1
1975 2
1976 5
1977 6
1978 8
1979 5
1980 9
1981 10
1982 22
1983 16
1984 18
1985 13
1986 20
1987 21
1988 22
1989 23
1990 23
1991 29
1992 33
1993 31
1994 36
1995 42
1996 38
1997 62
1998 79
1999 87
2000 94
2001 120
2002 131
2003 132
2004 190
2005 213
2006 250
2007 285
2008 344
2009 416
2010 450
2011 557
2012 662
2013 761
2014 757
2015 807
2016 490
2017 380
2018 527
2019 565
2020 587
2021 696
2022 588
2023 488
2024 92

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9,874 results

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Page 1
A cellular census of human lungs identifies novel cell states in health and in asthma.
Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA. Vieira Braga FA, et al. Among authors: gomes t. Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17. Nat Med. 2019. PMID: 31209336
We report the presence of pathogenic effector type 2 helper T cells (T(H)2) in asthmatic lungs and find evidence for type 2 cytokines in maintaining the altered epithelial cell states. Unbiased analysis of cell-cell interactions identifies a shift from airway struct …
We report the presence of pathogenic effector type 2 helper T cells (T(H)2) in asthmatic lungs and find evidence for type 2 cy …
Distinct microbial and immune niches of the human colon.
James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA. James KR, et al. Among authors: gomes t. Nat Immunol. 2020 Mar;21(3):343-353. doi: 10.1038/s41590-020-0602-z. Epub 2020 Feb 17. Nat Immunol. 2020. PMID: 32066951 Free PMC article.
Here, we simultaneously assess microbiota and single immune cells across the healthy, adult human colon, with paired characterization of immune cells in the mesenteric lymph nodes, to delineate colonic immune niches at steady state. We describe distinct helper T cell activ …
Here, we simultaneously assess microbiota and single immune cells across the healthy, adult human colon, with paired characterization of imm …
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
Miragaia RJ, Gomes T, Chomka A, Jardine L, Riedel A, Hegazy AN, Whibley N, Tucci A, Chen X, Lindeman I, Emerton G, Krausgruber T, Shields J, Haniffa M, Powrie F, Teichmann SA. Miragaia RJ, et al. Among authors: gomes t. Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001. Epub 2019 Feb 5. Immunity. 2019. PMID: 30737144 Free PMC article.
We used single-cell RNA-seq to characterize 35,000 CD4(+) regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their respective draining lymph nodes (LNs) and spleen. ...
We used single-cell RNA-seq to characterize 35,000 CD4(+) regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their …
Senescent T cells: Beneficial and detrimental roles.
Laphanuwat P, Gomes DCO, Akbar AN. Laphanuwat P, et al. Among authors: gomes dco. Immunol Rev. 2023 Jul;316(1):160-175. doi: 10.1111/imr.13206. Epub 2023 Apr 25. Immunol Rev. 2023. PMID: 37098109 Free PMC article. Review.
As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward rep …
As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells du …
SARS-CoV-2 uses CD4 to infect T helper lymphocytes.
Brunetti NS, Davanzo GG, de Moraes D, Ferrari AJR, Souza GF, Muraro SP, Knittel TL, Boldrini VO, Monteiro LB, Virgílio-da-Silva JV, Profeta GS, Wassano NS, Nunes Santos L, Carregari VC, Dias AHS, Veras FP, Tavares LA, Forato J, Castro IMS, Silva-Costa LC, Palma AC, Mansour E, Ulaf RG, Bernardes AF, Nunes TA, Ribeiro LC, Agrela MV, Moretti ML, Buscaratti LI, Crunfli F, Ludwig RG, Gerhardt JA, Munhoz-Alves N, Marques AM, Sesti-Costa R, Amorim MR, Toledo-Teixeira DA, Parise PL, Martini MC, Bispos-Dos-Santos K, Simeoni CL, Granja F, Silvestrini VC, de Oliveira EB, Faca VM, Carvalho M, Castelucci BG, Pereira AB, Coimbra LD, Dias MMG, Rodrigues PB, Gomes ABSP, Pereira FB, Santos LMB, Bloyet LM, Stumpf S, Pontelli MC, Whelan S, Sposito AC, Carvalho RF, Vieira AS, Vinolo MAR, Damasio A, Velloso L, Figueira ACM, da Silva LLP, Cunha TM, Nakaya HI, Marques-Souza H, Marques RE, Martins-de-Souza D, Skaf MS, Proenca-Modena JL, Moraes-Vieira PMM, Mori MA, Farias AS. Brunetti NS, et al. Among authors: gomes absp. Elife. 2023 Jul 31;12:e84790. doi: 10.7554/eLife.84790. Elife. 2023. PMID: 37523305 Free PMC article.
The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4(+) T helper cells, but not CD8(+) T cells, and is present in blood and bronchoalveolar lavage T …
The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-C …
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.
Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA. Henriksson J, et al. Among authors: gomes t. Cell. 2019 Feb 7;176(4):882-896.e18. doi: 10.1016/j.cell.2018.11.044. Epub 2019 Jan 10. Cell. 2019. PMID: 30639098 Free PMC article.
T helper type 2 (Th2) cells are important regulators of mammalian adaptive immunity and have relevance for infection, autoimmunity, and tumor immunology. ...
T helper type 2 (Th2) cells are important regulators of mammalian adaptive immunity and have relevance for infection, autoimmunity, a …
CAR-Ts: new perspectives in cancer therapy.
Abrantes R, Duarte HO, Gomes C, Wälchli S, Reis CA. Abrantes R, et al. Among authors: gomes c. FEBS Lett. 2022 Feb;596(4):403-416. doi: 10.1002/1873-3468.14270. Epub 2022 Jan 12. FEBS Lett. 2022. PMID: 34978080 Free article. Review.
CAR-T cell therapy also depends on the quality of the injected product, which is closely connected to CAR design. ...We also address potential future targets to overcome the flaws of CAR-T cell technology in the treatment of cancer, emphasizing glycan antigens, the …
CAR-T cell therapy also depends on the quality of the injected product, which is closely connected to CAR design. ...We also address …
Control of T cell effector functions by miRNAs.
Inácio DP, Amado T, Silva-Santos B, Gomes AQ. Inácio DP, et al. Among authors: gomes aq. Cancer Lett. 2018 Jul 28;427:63-73. doi: 10.1016/j.canlet.2018.04.011. Epub 2018 Apr 19. Cancer Lett. 2018. PMID: 29679611 Review.
This review summarises the role of individual miRNAs in the regulation of the differentiation of effector T cell subsets, including CD4(+) T helper cells, cytotoxic CD8(+) T cells and innate-like NKT cells. Moreover, we refer to miRNAs that have been identifi …
This review summarises the role of individual miRNAs in the regulation of the differentiation of effector T cell subsets, including C …
Chagas disease.
Teixeira AR, Nitz N, Guimaro MC, Gomes C, Santos-Buch CA. Teixeira AR, et al. Among authors: gomes c. Postgrad Med J. 2006 Dec;82(974):788-98. doi: 10.1136/pgmj.2006.047357. Postgrad Med J. 2006. PMID: 17148699 Free PMC article. Review.
Field studies predict that one third of an estimated 18 million T cruzi-infected humans in Latin America will die of Chagas disease. Acute infections are usually asymptomatic, but the ensuing chronic T cruzi infections have been associated with high ratios of morbid …
Field studies predict that one third of an estimated 18 million T cruzi-infected humans in Latin America will die of Chagas disease. …
The role of senescent T cells in immunopathology.
Covre LP, De Maeyer RPH, Gomes DCO, Akbar AN. Covre LP, et al. Among authors: gomes dco. Aging Cell. 2020 Dec;19(12):e13272. doi: 10.1111/acel.13272. Epub 2020 Nov 9. Aging Cell. 2020. PMID: 33166035 Free PMC article. Review.
Instead they recognize stress ligands that are induced by inflammation or infection of different cell types in tissues. In this article we discuss data on T cell senescence, how it is regulated and evidence for novel functional attributes of senescent T cells. We di …
Instead they recognize stress ligands that are induced by inflammation or infection of different cell types in tissues. In this article we d …
9,874 results