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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1967 1
1974 6
1975 57
1976 67
1977 94
1978 77
1979 86
1980 104
1981 111
1982 127
1983 132
1984 135
1985 174
1986 190
1987 299
1988 353
1989 421
1990 567
1991 714
1992 907
1993 1082
1994 1340
1995 1485
1996 1774
1997 2165
1998 2324
1999 2787
2000 3131
2001 3761
2002 4417
2003 6025
2004 7583
2005 9040
2006 10090
2007 11837
2008 14596
2009 17490
2010 21139
2011 25358
2012 30382
2013 35929
2014 40621
2015 43980
2016 29011
2017 21062
2018 31036
2019 35898
2020 41804
2021 46478
2022 51537
2023 44442
2024 10901

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545,575 results

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Page 1
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Zhang L, Yu X, Zheng L, Zhang Y, Li Y, Fang Q, Gao R, Kang B, Zhang Q, Huang JY, Konno H, Guo X, Ye Y, Gao S, Wang S, Hu X, Ren X, Shen Z, Ouyang W, Zhang Z. Zhang L, et al. Among authors: li y. Nature. 2018 Dec;564(7735):268-272. doi: 10.1038/s41586-018-0694-x. Epub 2018 Oct 29. Nature. 2018. PMID: 30479382
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T cells within tumours, remain unknown. ...Of the CD4(+) T cells, most tumour-infiltrating T regulatory (T(reg)) cel …
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T …
T cell senescence and CAR-T cell exhaustion in hematological malignancies.
Kasakovski D, Xu L, Li Y. Kasakovski D, et al. Among authors: li y. J Hematol Oncol. 2018 Jul 4;11(1):91. doi: 10.1186/s13045-018-0629-x. J Hematol Oncol. 2018. PMID: 29973238 Free PMC article. Review.
Chimeric antigen receptor T (CAR-T) cell and T cell receptor-engineered T (TCR-T) cell therapy highly rely on functionally active T cells. However, the mechanisms which drive T cell senescence remain unclear and controversial. In t …
Chimeric antigen receptor T (CAR-T) cell and T cell receptor-engineered T (TCR-T) cell therapy highly rel …
A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count.
Wang H, Tsao ST, Gu M, Fu C, He F, Li X, Zhang M, Li N, Hu HM. Wang H, et al. Among authors: li x, li n. J Transl Med. 2022 Dec 19;20(1):608. doi: 10.1186/s12967-022-03833-6. J Transl Med. 2022. PMID: 36536403 Free PMC article. Clinical Trial.
BACKGROUND: Chimeric antigen receptor T (CAR-T) cells are genetically modified T cells with redirected specificity and potent T-cell-mediated cytotoxicity toward malignant cells. ...CONCLUSIONS: In this study, we discovered that selecting CD3(+) T …
BACKGROUND: Chimeric antigen receptor T (CAR-T) cells are genetically modified T cells with redirected specificity and …
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. Park H, et al. Among authors: li z. Nat Immunol. 2005 Nov;6(11):1133-41. doi: 10.1038/ni1261. Epub 2005 Oct 2. Nat Immunol. 2005. PMID: 16200068 Free PMC article.
Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17. This process required the costimulatory molecules CD28 and ICOS but was independent of the cytokines and transc …
Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T help …
The role of T cells in pemphigus vulgaris and bullous pemphigoid.
Fang H, Li Q, Wang G. Fang H, et al. Among authors: li q. Autoimmun Rev. 2020 Nov;19(11):102661. doi: 10.1016/j.autrev.2020.102661. Epub 2020 Sep 14. Autoimmun Rev. 2020. PMID: 32942041 Review.
Th17 cells promote inflammatory response and skin damage, while regulatory T cells suppress autoreactive CD4(+) T cell activation and help control inflammation. ...In this review, we discuss the immune features of PV and BP, with a focus on the aberrations in T …
Th17 cells promote inflammatory response and skin damage, while regulatory T cells suppress autoreactive CD4(+) T cell activat …
Intratumoral CXCR5(+)CD8(+)T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.
Wang J, Li R, Cao Y, Gu Y, Fang H, Fei Y, Lv K, He X, Lin C, Liu H, Zhang H, Li H, He H, Xu J, Huang H. Wang J, et al. Among authors: li h, li r. Nat Commun. 2021 May 25;12(1):3080. doi: 10.1038/s41467-021-23356-w. Nat Commun. 2021. PMID: 34035252 Free PMC article.
Studies that examined an association between CD8(+)T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5(+)CD8(+)T associated with better overall survival has been reported among various malignancies. ...Microsatellite-unstable and E …
Studies that examined an association between CD8(+)T and prognosis in gastric cancer are inconsistent, and a distinct population of C …
Metabolic plasticity and regulation of T cell exhaustion.
Li F, Liu H, Zhang D, Ma Y, Zhu B. Li F, et al. Immunology. 2022 Dec;167(4):482-494. doi: 10.1111/imm.13575. Epub 2022 Sep 30. Immunology. 2022. PMID: 36088582 Free article. Review.
The metabolic reprogramming during T cell activation and differentiation affects T cell fate and immune responses. ...Here, we compiled the latest research on how T cell metabolism defines differentiation, focusing on T cell exhaustion during chronic i …
The metabolic reprogramming during T cell activation and differentiation affects T cell fate and immune responses. ...Here, we …
Metabolic dynamics instruct CD8(+) T-cell differentiation and functions.
Bevilacqua A, Li Z, Ho PC. Bevilacqua A, et al. Among authors: li z. Eur J Immunol. 2022 Apr;52(4):541-549. doi: 10.1002/eji.202149486. Epub 2022 Mar 16. Eur J Immunol. 2022. PMID: 35253907 Free PMC article. Review.
Cytotoxic CD8(+) T cells are a key element of the adaptative immune system to protect the organism against infections and malignant cells. ...However, it has also been recently appreciated that this metabolic reprogramming also directly supports T-cell lineage diffe …
Cytotoxic CD8(+) T cells are a key element of the adaptative immune system to protect the organism against infections and malignant c …
Immunotherapeutic Potential of T Memory Stem Cells.
Li Y, Wu D, Yang X, Zhou S. Li Y, et al. Front Oncol. 2021 Sep 17;11:723888. doi: 10.3389/fonc.2021.723888. eCollection 2021. Front Oncol. 2021. PMID: 34604060 Free PMC article. Review.
Memory T cells include T memory stem cells (T(SCM)) and central memory T cells (T(CM)). Compared with effector memory T cells (T(EM)) and effector T cells (T(EFF)), they have better durability and anti-tumor immunity. …
Memory T cells include T memory stem cells (T(SCM)) and central memory T cells (T(CM)). Compared with eff …
Current state of CAR-T therapy for T-cell malignancies.
Luo L, Zhou X, Zhou L, Liang Z, Yang J, Tu S, Li Y. Luo L, et al. Among authors: li y. Ther Adv Hematol. 2022 Dec 26;13:20406207221143025. doi: 10.1177/20406207221143025. eCollection 2022. Ther Adv Hematol. 2022. PMID: 36601636 Free PMC article. Review.
Moreover, T-cells collected for CAR transduction could be contaminated by malignant T-cells. ...Herein, we review the advances in promising target antigens, the current results of CAR-T therapy clinical trials in T-cell malignancies, the obstacles of C …
Moreover, T-cells collected for CAR transduction could be contaminated by malignant T-cells. ...Herein, we review the advances …
545,575 results
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