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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1951 1
1952 1
1955 2
1956 1
1957 1
1958 1
1962 1
1964 1
1966 1
1969 1
1972 4
1973 4
1974 8
1975 42
1976 45
1977 41
1978 50
1979 57
1980 98
1981 155
1982 156
1983 152
1984 190
1985 207
1986 219
1987 217
1988 250
1989 277
1990 344
1991 293
1992 364
1993 337
1994 343
1995 412
1996 397
1997 397
1998 414
1999 483
2000 542
2001 629
2002 617
2003 703
2004 907
2005 1073
2006 1155
2007 1339
2008 1509
2009 1780
2010 2019
2011 2459
2012 2790
2013 2962
2014 3425
2015 3506
2016 2385
2017 1874
2018 2522
2019 2786
2020 3291
2021 3883
2022 3794
2023 2988
2024 420

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50,814 results

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Page 1
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering.
Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Billingsley MM, et al. Among authors: singh n. Nano Lett. 2020 Mar 11;20(3):1578-1589. doi: 10.1021/acs.nanolett.9b04246. Epub 2020 Feb 5. Nano Lett. 2020. PMID: 31951421 Free PMC article.
CAR T cells engineered via C14-4 LNP treatment were then compared to electroporated CAR T cells in a coculture assay with Nalm-6 acute lymphoblastic leukemia cells, and both CAR T cell engineering methods elicited potent cancer-killing activity. These results …
CAR T cells engineered via C14-4 LNP treatment were then compared to electroporated CAR T cells in a coculture assay with Nalm …
CAR T cells: continuation in a revolution of immunotherapy.
Singh AK, McGuirk JP. Singh AK, et al. Lancet Oncol. 2020 Mar;21(3):e168-e178. doi: 10.1016/S1470-2045(19)30823-X. Lancet Oncol. 2020. PMID: 32135120 Review.
Immunotherapy is now considered the fifth pillar of cancer care, alongside surgery, chemotherapy, radiotherapy, and targeted therapy. Recently, the success of genetically modified T cells that express chimeric antigen receptors (CAR T cells) has generated considerab …
Immunotherapy is now considered the fifth pillar of cancer care, alongside surgery, chemotherapy, radiotherapy, and targeted therapy. Recent …
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens.
Damo M, Hornick NI, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza JL, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky WE, Leventhal JS, Krishnaswamy S, Joshi NS. Damo M, et al. Among authors: singh j. Nature. 2023 Jul;619(7968):151-159. doi: 10.1038/s41586-023-06217-y. Epub 2023 Jun 21. Nature. 2023. PMID: 37344588 Free PMC article.
The peripheral T cell repertoire of healthy individuals contains self-reactive T cells(1,2). ...Here we developed a mouse model in which skin-specific expression of T cell antigens in the epidermis caused local infiltration of antigen-specific CD8 T ce …
The peripheral T cell repertoire of healthy individuals contains self-reactive T cells(1,2). ...Here we developed a mouse mode …
Chimeric antigen receptor T cell: A cancer immunotherapy.
Singh S, Khasbage S, Kaur RJ, Sidhu JK, Bhandari B. Singh S, et al. Indian J Pharmacol. 2022 May-Jun;54(3):226-233. doi: 10.4103/ijp.ijp_531_20. Indian J Pharmacol. 2022. PMID: 35848695 Free PMC article. Review.
Research on development of various types of ACT immunotherapy is going on, but so far, Chimeric antigen receptors T cell therapy (CAR-T) has achieved the maximum advancement in terms of clinical development. CARs are the modified receptors that integrates specificit …
Research on development of various types of ACT immunotherapy is going on, but so far, Chimeric antigen receptors T cell therapy (CAR …
Pancreatic islet-specific engineered T(regs) exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
Yang SJ, Singh AK, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, Linsley PS, Cerosaletti K, Mauk K, Xiang Y, Smith J, Mortensen E, Cook PJ, Sommer K, Khan I, Liggitt D, Rawlings DJ, Buckner JH. Yang SJ, et al. Among authors: singh ak. Sci Transl Med. 2022 Oct 5;14(665):eabn1716. doi: 10.1126/scitranslmed.abn1716. Epub 2022 Oct 5. Sci Transl Med. 2022. PMID: 36197963
Adoptive transfer of regulatory T cells (T(regs)) is therapeutic in type 1 diabetes (T1D) mouse models. T(regs) that are specific for pancreatic islets are more potent than polyclonal T(regs) in preventing disease. ...
Adoptive transfer of regulatory T cells (T(regs)) is therapeutic in type 1 diabetes (T1D) mouse models. T(regs) that ar …
Mechanism of thioflavin T binding to amyloid fibrils.
Khurana R, Coleman C, Ionescu-Zanetti C, Carter SA, Krishna V, Grover RK, Roy R, Singh S. Khurana R, et al. Among authors: singh s. J Struct Biol. 2005 Sep;151(3):229-38. doi: 10.1016/j.jsb.2005.06.006. J Struct Biol. 2005. PMID: 16125973
Interestingly, changes in the fluorescence excitation and emission of thioflavin T were also dependent on the micelle formation. The thioflavin T micelles of 3 nm diameter were directly visualized using atomic force microscopy, and bound thioflavin T micelles …
Interestingly, changes in the fluorescence excitation and emission of thioflavin T were also dependent on the micelle formation. The …
TCF-1 controls T(reg) cell functions that regulate inflammation, CD8(+) T cell cytotoxicity and severity of colon cancer.
Osman A, Yan B, Li Y, Pavelko KD, Quandt J, Saadalla A, Singh MP, Kazemian M, Gounari F, Khazaie K. Osman A, et al. Among authors: singh mp. Nat Immunol. 2021 Sep;22(9):1152-1162. doi: 10.1038/s41590-021-00987-1. Epub 2021 Aug 12. Nat Immunol. 2021. PMID: 34385712 Free PMC article.
TCF-1-deficient T(reg) cells strongly suppressed T cell proliferation and cytotoxicity, but were compromised in controlling CD4(+) T cell polarization and inflammation. ...Thus, T(reg) cell-specific TCF-1 expression differentially regulates T(H) …
TCF-1-deficient T(reg) cells strongly suppressed T cell proliferation and cytotoxicity, but were compromised in controlling CD …
Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.
Hurton LV, Singh H, Najjar AM, Switzer KC, Mi T, Maiti S, Olivares S, Rabinovich B, Huls H, Forget MA, Datar V, Kebriaei P, Lee DA, Champlin RE, Cooper LJ. Hurton LV, et al. Among authors: singh h. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7788-E7797. doi: 10.1073/pnas.1610544113. Epub 2016 Nov 14. Proc Natl Acad Sci U S A. 2016. PMID: 27849617 Free PMC article.
T-memory stem cells (T(SCM)) retain superior potential for long-lived persistence, but challenges exist in manufacturing this T-cell subset because they are rare among circulating lymphocytes. We report a clinically relevant approach to generating CAR(+) T
T-memory stem cells (T(SCM)) retain superior potential for long-lived persistence, but challenges exist in manufacturing this
Introductory perspective.
Singh H. Singh H. Semin Immunol. 2011 Oct;23(5):315-6. doi: 10.1016/j.smim.2011.10.003. Semin Immunol. 2011. PMID: 22082671 No abstract available.
Advances in CAR design.
Heard A, Chang J, Warrington JM, Singh N. Heard A, et al. Among authors: singh n. Best Pract Res Clin Haematol. 2021 Sep;34(3):101304. doi: 10.1016/j.beha.2021.101304. Epub 2021 Aug 26. Best Pract Res Clin Haematol. 2021. PMID: 34625230 Review.
Chimeric antigen receptor (CAR) T cells have revolutionized the management of B cell malignancies. These synthetic molecules are composed of peptide fragments from several distinct immune cell proteins and link highly-specific antigen recognition with potent T cell …
Chimeric antigen receptor (CAR) T cells have revolutionized the management of B cell malignancies. These synthetic molecules are comp …
50,814 results
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