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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1963 1
1964 1
1965 2
1966 1
1967 3
1969 1
1970 2
1971 9
1972 3
1974 2
1975 13
1976 16
1977 34
1978 30
1979 20
1980 84
1981 140
1982 193
1983 239
1984 222
1985 268
1986 269
1987 322
1988 358
1989 385
1990 376
1991 483
1992 535
1993 561
1994 585
1995 636
1996 654
1997 672
1998 723
1999 788
2000 880
2001 893
2002 985
2003 1054
2004 1081
2005 1165
2006 1261
2007 1326
2008 1395
2009 1421
2010 1615
2011 1734
2012 1882
2013 1892
2014 1895
2015 1842
2016 1196
2017 986
2018 1311
2019 1309
2020 1561
2021 1590
2022 1427
2023 1154
2024 181

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37,738 results

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Page 1
Peripheral T cell expansion predicts tumour infiltration and clinical response.
Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Delamarre L, Mellman I, Bourgon R, Grogan JL. Wu TD, et al. Among authors: takahashi c. Nature. 2020 Mar;579(7798):274-278. doi: 10.1038/s41586-020-2056-8. Epub 2020 Feb 26. Nature. 2020. PMID: 32103181
Here, by performing deep single-cell sequencing of RNA and T cell receptors in patients with different types of cancer, we survey the profiles of various populations of T cells and T cell receptors in tumours, normal adjacent tissue, and peripheral blood. We …
Here, by performing deep single-cell sequencing of RNA and T cell receptors in patients with different types of cancer, we survey the …
Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases.
Iriki H, Takahashi H, Amagai M. Iriki H, et al. Among authors: takahashi h. J Invest Dermatol. 2023 Apr;143(4):545-553. doi: 10.1016/j.jid.2022.11.009. Epub 2023 Feb 25. J Invest Dermatol. 2023. PMID: 36842860 Free article. Review.
OX40 is an important costimulatory molecule for T-cell expansion and survival. Because OX40 is expressed on most T-cell subsets, it is an attractive therapeutic target for a variety of T-cell-mediated diseases. ...In this review, we present various observatio …
OX40 is an important costimulatory molecule for T-cell expansion and survival. Because OX40 is expressed on most T-cell subset …
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells.
Wang B, Iriguchi S, Waseda M, Ueda N, Ueda T, Xu H, Minagawa A, Ishikawa A, Yano H, Ishi T, Ito R, Goto M, Takahashi R, Uemura Y, Hotta A, Kaneko S. Wang B, et al. Among authors: takahashi r. Nat Biomed Eng. 2021 May;5(5):429-440. doi: 10.1038/s41551-021-00730-z. Epub 2021 May 17. Nat Biomed Eng. 2021. PMID: 34002062
Avoiding the immune rejection of transplanted T cells is central to the success of allogeneic cancer immunotherapies. ...Hypoimmunogenic iPSC-derived T cells may contribute to the creation of off-the-shelf T cell immunotherapies....
Avoiding the immune rejection of transplanted T cells is central to the success of allogeneic cancer immunotherapies. ...Hypoimmunoge …
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Nishimura T, et al. Among authors: takahashi s. Cell Stem Cell. 2013 Jan 3;12(1):114-26. doi: 10.1016/j.stem.2012.11.002. Cell Stem Cell. 2013. PMID: 23290140 Free article.
In an effort to overcome this problem, we reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency. The T cell-derived induced pluripotent stem cells were then redifferentiated into CD8(+) T cells that had …
In an effort to overcome this problem, we reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patie …
Tissue-resident CD4(+) T helper cells assist the development of protective respiratory B and CD8(+) T cell memory responses.
Son YM, Cheon IS, Wu Y, Li C, Wang Z, Gao X, Chen Y, Takahashi Y, Fu YX, Dent AL, Kaplan MH, Taylor JJ, Cui W, Sun J. Son YM, et al. Among authors: takahashi y. Sci Immunol. 2021 Jan 8;6(55):eabb6852. doi: 10.1126/sciimmunol.abb6852. Sci Immunol. 2021. PMID: 33419791 Free PMC article.
We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and T(RM) cells, and we have termed these cells as resident helper T (T(RH)) cells. ...We show that T(RH) cells deliver local …
We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and T(R …
Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy.
Yoshikawa T, Wu Z, Inoue S, Kasuya H, Matsushita H, Takahashi Y, Kuroda H, Hosoda W, Suzuki S, Kagoya Y. Yoshikawa T, et al. Among authors: takahashi y. Blood. 2022 Apr 7;139(14):2156-2172. doi: 10.1182/blood.2021012714. Blood. 2022. PMID: 34861037 Free article.
PRDM1 disruption promoted the expansion of less differentiated memory CAR-T cells in vivo, which enhanced T-cell persistence and improved therapeutic efficacy in multiple tumor models. ...PRDM1 knockout also facilitated maintaining an early memory phenotype and cyto …
PRDM1 disruption promoted the expansion of less differentiated memory CAR-T cells in vivo, which enhanced T-cell persistence a …
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy.
Abbas HA, Hao D, Tomczak K, Barrodia P, Im JS, Reville PK, Alaniz Z, Wang W, Wang R, Wang F, Al-Atrash G, Takahashi K, Ning J, Ding M, Beird HC, Mathews JT, Little L, Zhang J, Basu S, Konopleva M, Marques-Piubelli ML, Solis LM, Parra ER, Lu W, Tamegnon A, Garcia-Manero G, Green MR, Sharma P, Allison JP, Kornblau SM, Rai K, Wang L, Daver N, Futreal A. Abbas HA, et al. Among authors: takahashi k. Nat Commun. 2021 Oct 18;12(1):6071. doi: 10.1038/s41467-021-26282-z. Nat Commun. 2021. PMID: 34663807 Free PMC article.
In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest responses are achieved with checkpoint-blockade therapy, which might be explained by T cell phenotypes and T cell receptor (TC …
In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest …
Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H. Komuro H, et al. Among authors: takahashi y. J Immunother Cancer. 2023 Aug;11(8):e007180. doi: 10.1136/jitc-2023-007180. J Immunother Cancer. 2023. PMID: 37544663 Free PMC article.
An exhausted T-cell (exhausted T (Tex)) cluster characterized by the expression of ENTPD1 (CD39), TOX, PDCD1 (PD1), HAVCR2 (TIM3) and other genes, and by T-cell oligoclonality, was identified. ...Stimulating these T cells with predicted cognate peptide …
An exhausted T-cell (exhausted T (Tex)) cluster characterized by the expression of ENTPD1 (CD39), TOX, PDCD1 (PD1), HAVCR2 (TI …
A Comprehensive Study of the Immunophenotype and its Clinicopathologic Significance in Adult T-Cell Leukemia/Lymphoma.
Tamaki T, Karube K, Sakihama S, Tsuruta Y, Awazawa R, Hayashi M, Nakada N, Matsumoto H, Yagi N, Ohshiro K, Nakazato I, Kitamura S, Nishi Y, Miyagi T, Yamaguchi S, Nakachi S, Morishima S, Masuzaki H, Takahashi K, Fukushima T, Wada N. Tamaki T, et al. Among authors: takahashi k. Mod Pathol. 2023 Aug;36(8):100169. doi: 10.1016/j.modpat.2023.100169. Epub 2023 Mar 29. Mod Pathol. 2023. PMID: 36997002 Free article.
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). ...Furthermore, the expression status of novel markers associated with T-cell lymphomas, including Th1 markers (T-bet and CXCR3) …
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). .. …
T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen.
Takahashi H, Iriki H, Asahina Y. Takahashi H, et al. J Dermatol. 2023 Feb;50(2):112-123. doi: 10.1111/1346-8138.16663. Epub 2022 Dec 20. J Dermatol. 2023. PMID: 36539957 Free PMC article. Review.
Research on the role of T cells in pemphigus has continued to progress, including that on T follicular helper cells, which initiate molecular mechanisms involved in antibody production in B cells. ...The mouse research has helped elucidate novel regulatory mechanism …
Research on the role of T cells in pemphigus has continued to progress, including that on T follicular helper cells, which ini …
37,738 results
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