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The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.
Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, Santos MM, Morales CR, Pantopoulos K, Sonenberg N, Pinho S, Tahmasebi S. Toboz P, et al. Among authors: tabatabaei n. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2121251119. doi: 10.1073/pnas.2121251119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994670 Free PMC article.
The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Farooq Z, Kusuma F, Burke P, Dufour CR, Lee D, Tabatabaei N, Toboz P, Radovani E, Greenblatt JF, Rehman J, Class J, Khoutorsky A, Fonseca BD, Richner JM, Mercier E, Bourque G, Giguère V, Subramaniam AR, Han J, Tahmasebi S. Farooq Z, et al. Among authors: tabatabaei n. J Biol Chem. 2022 Sep;298(9):102277. doi: 10.1016/j.jbc.2022.102277. Epub 2022 Jul 19. J Biol Chem. 2022. PMID: 35863436 Free PMC article.
58 results