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Page 1
Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer.
Murayama T, Nakayama J, Jiang X, Miyata K, Morris AD, Cai KQ, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim W, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Cañadas I. Murayama T, et al. Cancer Discov. 2024 Mar 1;14(3):468-491. doi: 10.1158/2159-8290.CD-23-0486. Cancer Discov. 2024. PMID: 38189443 Free PMC article.
Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.
Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigí M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Cañadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Jänne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA. Mahadevan NR, et al. Among authors: murayama t. Cancer Discov. 2021 Aug;11(8):1952-1969. doi: 10.1158/2159-8290.CD-20-0913. Epub 2021 Mar 11. Cancer Discov. 2021. PMID: 33707236 Free PMC article.
The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
Takeuchi Y, Kimura N, Murayama T, Machida Y, Iejima D, Nishimura T, Terashima M, Wang Y, Li M, Sakamoto R, Yamamoto M, Itano N, Inoue Y, Ito M, Yoshida N, Inoue JI, Akashi K, Saya H, Fujita K, Kuroda M, Kitabayashi I, Voon D, Suzuki T, Tojo A, Gotoh N. Takeuchi Y, et al. Among authors: murayama t. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2103658118. doi: 10.1073/pnas.2103658118. Proc Natl Acad Sci U S A. 2021. PMID: 34663724 Free PMC article.
MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells.
Murayama T, Takeuchi Y, Yamawaki K, Natsume T, Li M, Marcela RN, Nishimura T, Kogure Y, Nakata A, Tominaga K, Sasahara A, Yano M, Ishikawa S, Ohta T, Ikeda K, Horie-Inoue K, Inoue S, Seki M, Suzuki Y, Sugano S, Enomoto T, Tanabe M, Tada KI, Kanemaki MT, Okamoto K, Tojo A, Gotoh N. Murayama T, et al. Cancer Sci. 2021 Mar;112(3):1209-1224. doi: 10.1111/cas.14776. Epub 2021 Jan 22. Cancer Sci. 2021. PMID: 33340428 Free PMC article.
Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma.
Hirano M, Imai Y, Kaito Y, Murayama T, Sato K, Ishida T, Yamamoto J, Ito T, Futami M, Ri M, Yasui H, Denda T, Tanaka Y, Ota Y, Nojima M, Kamikubo Y, Gotoh N, Iida S, Handa H, Tojo A. Hirano M, et al. Among authors: murayama t. J Exp Clin Cancer Res. 2021 Mar 23;40(1):110. doi: 10.1186/s13046-021-01909-7. J Exp Clin Cancer Res. 2021. PMID: 33757580 Free PMC article.
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N. Nishimura T, et al. Among authors: murayama t. Oncogene. 2019 Apr;38(14):2464-2481. doi: 10.1038/s41388-018-0589-1. Epub 2018 Dec 7. Oncogene. 2019. PMID: 30532069 Free PMC article.
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Tominaga K, Minato H, Murayama T, Sasahara A, Nishimura T, Kiyokawa E, Kanauchi H, Shimizu S, Sato A, Nishioka K, Tsuji EI, Yano M, Ogawa T, Ishii H, Mori M, Akashi K, Okamoto K, Tanabe M, Tada KI, Tojo A, Gotoh N. Tominaga K, et al. Among authors: murayama t. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):625-630. doi: 10.1073/pnas.1806851116. Epub 2018 Dec 26. Proc Natl Acad Sci U S A. 2019. PMID: 30587593 Free PMC article.