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Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds.
Elife. 2022 Aug 1;11:e75531. doi: 10.7554/eLife.75531.
Elife. 2022.
PMID: 35913044
Free PMC article.
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action.
Mitchell W, Ng EA, Tamucci JD, Boyd KJ, Sathappa M, Coscia A, Pan M, Han X, Eddy NA, May ER, Szeto HH, Alder NN.
Mitchell W, et al. Among authors: tamucci jd.
J Biol Chem. 2020 May 22;295(21):7452-7469. doi: 10.1074/jbc.RA119.012094. Epub 2020 Apr 9.
J Biol Chem. 2020.
PMID: 32273339
Free PMC article.
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Peptide Power: Mechanistic Insights into the Effect of Mitochondria-Targeted Tetrapeptides on Membrane Electrostatics from Molecular Simulations.
Tamucci JD, Alder NN, May ER.
Tamucci JD, et al.
Mol Pharm. 2023 Dec 4;20(12):6114-6129. doi: 10.1021/acs.molpharmaceut.3c00480. Epub 2023 Oct 30.
Mol Pharm. 2023.
PMID: 37904323
Free PMC article.
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