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2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists.
Kobayashi K, Uchiyama M, Takahashi H, Kawamoto H, Ito S, Yoshizumi T, Nakashima H, Kato T, Shimizu A, Yamamoto I, Asai M, Miyazoe H, Ohno A, Hirayama M, Ozaki S, Tani T, Ishii Y, Tanaka T, Mochidome T, Tadano K, Fukuroda T, Ohta H, Okamoto O. Kobayashi K, et al. Among authors: tanaka t. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3096-9. doi: 10.1016/j.bmcl.2009.04.023. Epub 2009 Apr 11. Bioorg Med Chem Lett. 2009. PMID: 19394217
A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.
Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T. Ishihara A, et al. Among authors: tanaka t. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7154-8. doi: 10.1073/pnas.0510320103. Epub 2006 Apr 24. Proc Natl Acad Sci U S A. 2006. PMID: 16636293 Free PMC article.
Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist.
Ishihara A, Kanatani A, Okada M, Hidaka M, Tanaka T, Mashiko S, Gomori A, Kanno T, Hata M, Kanesaka M, Tominaga Y, Sato NA, Kobayashi M, Murai T, Watanabe K, Ishii Y, Fukuroda T, Fukami T, Ihara M. Ishihara A, et al. Among authors: tanaka t. Br J Pharmacol. 2002 Jun;136(3):341-6. doi: 10.1038/sj.bjp.0704696. Br J Pharmacol. 2002. PMID: 12023935 Free PMC article.
Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity.
Kameda M, Kobayashi K, Ito H, Miyazoe H, Tsujino T, Nakama C, Kawamoto H, Ando M, Ito S, Suzuki T, Kanno T, Tanaka T, Tahara Y, Tani T, Tanaka S, Tokita S, Sato N. Kameda M, et al. Among authors: tanaka t, tanaka s. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4325-9. doi: 10.1016/j.bmcl.2009.05.069. Epub 2009 May 24. Bioorg Med Chem Lett. 2009. PMID: 19487123
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