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A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Marchand A, Sarchione A, Athanasopoulos PS, Roy HB, Goveas L, Magnez R, Drouyer M, Emanuele M, Ho FY, Liberelle M, Melnyk P, Lebègue N, Thuru X, Nichols RJ, Greggio E, Kortholt A, Galli T, Chartier-Harlin MC, Taymans JM. Marchand A, et al. Among authors: taymans jm. Cells. 2022 Mar 17;11(6):1018. doi: 10.3390/cells11061018. Cells. 2022. PMID: 35326469 Free PMC article.
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.
Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. Greggio E, et al. Among authors: taymans jm. J Biol Chem. 2008 Jun 13;283(24):16906-14. doi: 10.1074/jbc.M708718200. Epub 2008 Apr 8. J Biol Chem. 2008. PMID: 18397888 Free PMC article.
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR. Greggio E, et al. Among authors: taymans jm. Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3. Biochem Biophys Res Commun. 2009. PMID: 19733152 Free PMC article.
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Daniëls V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, Taymans JM. Daniëls V, et al. Among authors: taymans jm. J Neurochem. 2011 Jan;116(2):304-15. doi: 10.1111/j.1471-4159.2010.07105.x. J Neurochem. 2011. PMID: 21073465 Free PMC article.
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Civiero L, Vancraenenbroeck R, Belluzzi E, Beilina A, Lobbestael E, Reyniers L, Gao F, Micetic I, De Maeyer M, Bubacco L, Baekelandt V, Cookson MR, Greggio E, Taymans JM. Civiero L, et al. Among authors: taymans jm. PLoS One. 2012;7(8):e43472. doi: 10.1371/journal.pone.0043472. Epub 2012 Aug 29. PLoS One. 2012. PMID: 22952686 Free PMC article.
The GTPase function of LRRK2.
Taymans JM. Taymans JM. Biochem Soc Trans. 2012 Oct;40(5):1063-9. doi: 10.1042/BST20120133. Biochem Soc Trans. 2012. PMID: 22988866 Review.
Phosphorylation of LRRK2: from kinase to substrate.
Lobbestael E, Baekelandt V, Taymans JM. Lobbestael E, et al. Among authors: taymans jm. Biochem Soc Trans. 2012 Oct;40(5):1102-10. doi: 10.1042/BST20120128. Biochem Soc Trans. 2012. PMID: 22988873 Review.
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA; International Parkinson’s Disease Genomics Consortium; North American Brain Expression Consortium; Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR. Beilina A, et al. Among authors: taymans jm. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31. doi: 10.1073/pnas.1318306111. Epub 2014 Feb 7. Proc Natl Acad Sci U S A. 2014. PMID: 24510904 Free PMC article.
69 results