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Page 1
Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion.
Sci Rep. 2019 Jan 22;9(1):310. doi: 10.1038/s41598-018-36559-x.
Sci Rep. 2019.
PMID: 30670736
Free PMC article.
Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells.
Barzadd MM, Lundqvist M, Harris C, Malm M, Volk AL, Thalén N, Chotteau V, Grassi L, Smith A, Abadi ML, Lambiase G, Gibson S, Hatton D, Rockberg J.
Barzadd MM, et al. Among authors: thalen n.
N Biotechnol. 2022 May 25;68:68-76. doi: 10.1016/j.nbt.2022.01.010. Epub 2022 Feb 2.
N Biotechnol. 2022.
PMID: 35123066
Free article.
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Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome.
Hendrikse NM, Sandegren A, Andersson T, Blomqvist J, Makower Å, Possner D, Su C, Thalén N, Tjernberg A, Westermark U, Rockberg J, Svensson Gelius S, Syrén PO, Nordling E.
Hendrikse NM, et al. Among authors: thalen n.
iScience. 2021 Feb 6;24(3):102154. doi: 10.1016/j.isci.2021.102154. eCollection 2021 Mar 19.
iScience. 2021.
PMID: 33665572
Free PMC article.
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Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold.
Thalén NB, Barzadd MM, Lundqvist M, Rodhe J, Andersson M, Bidkhori G, Possner D, Su C, Nilsson J, Eisenhut P, Malm M, Karlsson A, Vestin J, Forsberg J, Nordling E, Mardinoglu A, Volk AL, Sandegren A, Rockberg J.
Thalén NB, et al.
Metab Eng. 2024 Jan;81:157-166. doi: 10.1016/j.ymben.2023.12.003. Epub 2023 Dec 9.
Metab Eng. 2024.
PMID: 38081506
Free article.
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Systematic use of synthetic 5'-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories.
Eisenhut P, Mebrahtu A, Moradi Barzadd M, Thalén N, Klanert G, Weinguny M, Sandegren A, Su C, Hatton D, Borth N, Rockberg J.
Eisenhut P, et al. Among authors: thalen n.
Nucleic Acids Res. 2020 Nov 18;48(20):e119. doi: 10.1093/nar/gkaa847.
Nucleic Acids Res. 2020.
PMID: 33051690
Free PMC article.
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