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SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.
Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.
Biochem J. 2012.
PMID: 22032326
Free PMC article.
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.
Vitari AC, et al.
Biochem J. 2006 Jul 1;397(1):223-31. doi: 10.1042/BJ20060220.
Biochem J. 2006.
PMID: 16669787
Free PMC article.
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Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR.
Zagórska A, et al.
J Cell Biol. 2007 Jan 1;176(1):89-100. doi: 10.1083/jcb.200605093. Epub 2006 Dec 26.
J Cell Biol. 2007.
PMID: 17190791
Free PMC article.
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Structural insights into the recognition of substrates and activators by the OSR1 kinase.
Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM.
Villa F, et al.
EMBO Rep. 2007 Sep;8(9):839-45. doi: 10.1038/sj.embor.7401048. Epub 2007 Aug 17.
EMBO Rep. 2007.
PMID: 17721439
Free PMC article.
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