Thatcher GR - Search Results

1

Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.

Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher GR, Bolton JL. Yu L, et al. Among authors: thatcher gr. Chem Res Toxicol. 2004 Jul;17(7):879-88. doi: 10.1021/tx0342722. Chem Res Toxicol. 2004. PMID: 15257612

2

Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.

Toader V, Xu X, Nicolescu A, Yu L, Bolton JL, Thatcher GR. Toader V, et al. Among authors: thatcher gr. Chem Res Toxicol. 2003 Oct;16(10):1264-76. doi: 10.1021/tx025641h. Chem Res Toxicol. 2003. PMID: 14565768

3

Quinoids formed from estrogens and antiestrogens.

Bolton JL, Yu L, Thatcher GR. Bolton JL, et al. Among authors: thatcher gr. Methods Enzymol. 2004;378:110-23. doi: 10.1016/S0076-6879(04)78006-4. Methods Enzymol. 2004. PMID: 15038960 Review. No abstract available.

4

Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.

Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Liu H, et al. Among authors: thatcher gr. Chem Res Toxicol. 2005 Feb;18(2):162-73. doi: 10.1021/tx049776u. Chem Res Toxicol. 2005. PMID: 15720120

5

Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.

Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Liu J, et al. Among authors: thatcher gr. Chem Res Toxicol. 2005 Feb;18(2):174-82. doi: 10.1021/tx0497752. Chem Res Toxicol. 2005. PMID: 15720121

6

Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.

Liu J, Li Q, Yang X, van Breemen RB, Bolton JL, Thatcher GR. Liu J, et al. Among authors: thatcher gr. Chem Res Toxicol. 2005 Sep;18(9):1485-96. doi: 10.1021/tx0501738. Chem Res Toxicol. 2005. PMID: 16167842 Free PMC article.

7

Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.

Liu H, Bolton JL, Thatcher GR. Liu H, et al. Among authors: thatcher gr. Chem Res Toxicol. 2006 Jun;19(6):779-87. doi: 10.1021/tx050326r. Chem Res Toxicol. 2006. PMID: 16780356 Free PMC article.

8

Bioactivation of Selective Estrogen Receptor Modulators (SERMs).

Dowers TS, Qin ZH, Thatcher GR, Bolton JL. Dowers TS, et al. Among authors: thatcher gr. Chem Res Toxicol. 2006 Sep;19(9):1125-37. doi: 10.1021/tx060126v. Chem Res Toxicol. 2006. PMID: 16978016 Free PMC article. Review. No abstract available.

9

Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.

Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Qin Z, et al. Among authors: thatcher gr. J Med Chem. 2007 May 31;50(11):2682-92. doi: 10.1021/jm070079j. Epub 2007 May 10. J Med Chem. 2007. PMID: 17489582

10

Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.

Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Chang M, et al. Among authors: thatcher gr. Endocrinology. 2007 Oct;148(10):4793-802. doi: 10.1210/en.2006-1568. Epub 2007 Jun 21. Endocrinology. 2007. PMID: 17584965

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