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2021 | 1 |
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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake.
J Control Release. 2018 Dec 10;291:106-115. doi: 10.1016/j.jconrel.2018.10.015. Epub 2018 Oct 15.
J Control Release. 2018.
PMID: 30336167
Free PMC article.
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).
Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR.
Parhiz H, et al. Among authors: uhler t.
J Control Release. 2022 Apr;344:50-61. doi: 10.1016/j.jconrel.2021.12.027. Epub 2021 Dec 23.
J Control Release. 2022.
PMID: 34953981
Free PMC article.
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Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude.
Brenner JS, Pan DC, Myerson JW, Marcos-Contreras OA, Villa CH, Patel P, Hekierski H, Chatterjee S, Tao JQ, Parhiz H, Bhamidipati K, Uhler TG, Hood ED, Kiseleva RY, Shuvaev VS, Shuvaeva T, Khoshnejad M, Johnston I, Gregory JV, Lahann J, Wang T, Cantu E, Armstead WM, Mitragotri S, Muzykantov V.
Brenner JS, et al. Among authors: uhler tg.
Nat Commun. 2018 Jul 11;9(1):2684. doi: 10.1038/s41467-018-05079-7.
Nat Commun. 2018.
PMID: 29992966
Free PMC article.
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