Thoolen M - Search Results

1

Initial experience in the treatment of inherited mitochondrial disease with EPI-743.

Enns GM, Kinsman SL, Perlman SL, Spicer KM, Abdenur JE, Cohen BH, Amagata A, Barnes A, Kheifets V, Shrader WD, Thoolen M, Blankenberg F, Miller G. Enns GM, et al. Among authors: thoolen m. Mol Genet Metab. 2012 Jan;105(1):91-102. doi: 10.1016/j.ymgme.2011.10.009. Epub 2011 Oct 21. Mol Genet Metab. 2012. PMID: 22115768 Free article. Clinical Trial.

2

EPI-743 reverses the progression of the pediatric mitochondrial disease--genetically defined Leigh Syndrome.

Martinelli D, Catteruccia M, Piemonte F, Pastore A, Tozzi G, Dionisi-Vici C, Pontrelli G, Corsetti T, Livadiotti S, Kheifets V, Hinman A, Shrader WD, Thoolen M, Klein MB, Bertini E, Miller G. Martinelli D, et al. Among authors: thoolen m. Mol Genet Metab. 2012 Nov;107(3):383-8. doi: 10.1016/j.ymgme.2012.09.007. Epub 2012 Sep 10. Mol Genet Metab. 2012. PMID: 23010433 Clinical Trial.

3

Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial disease.

Blankenberg FG, Kinsman SL, Cohen BH, Goris ML, Spicer KM, Perlman SL, Krane EJ, Kheifets V, Thoolen M, Miller G, Enns GM. Blankenberg FG, et al. Among authors: thoolen m. Mol Genet Metab. 2012 Dec;107(4):690-9. doi: 10.1016/j.ymgme.2012.09.023. Epub 2012 Sep 28. Mol Genet Metab. 2012. PMID: 23084792

4

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.

Shrader WD, Amagata A, Barnes A, Enns GM, Hinman A, Jankowski O, Kheifets V, Komatsuzaki R, Lee E, Mollard P, Murase K, Sadun AA, Thoolen M, Wesson K, Miller G. Shrader WD, et al. Among authors: thoolen m. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8. doi: 10.1016/j.bmcl.2011.04.085. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21600768

5

Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy.

Sadun AA, Chicani CF, Ross-Cisneros FN, Barboni P, Thoolen M, Shrader WD, Kubis K, Carelli V, Miller G. Sadun AA, et al. Among authors: thoolen m. Arch Neurol. 2012 Mar;69(3):331-8. doi: 10.1001/archneurol.2011.2972. Arch Neurol. 2012. PMID: 22410442

6

Evaluation of vatiquinone drug-drug interaction potential in vitro and in a phase 1 clinical study with tolbutamide, a CYP2C9 substrate, and omeprazole, a CYP2C19 substrate, in healthy subjects.

Murase K, Lee L, Ma J, Barrett R, Thoolen M. Murase K, et al. Among authors: thoolen m. Eur J Clin Pharmacol. 2022 Nov;78(11):1823-1831. doi: 10.1007/s00228-022-03393-0. Epub 2022 Sep 27. Eur J Clin Pharmacol. 2022. PMID: 36166059 Clinical Trial.

7

Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.

Taygerly JP, McGee LR, Rubenstein SM, Houze JB, Cushing TD, Li Y, Motani A, Chen JL, Frankmoelle W, Ye G, Learned MR, Jaen J, Miao S, Timmermans PB, Thoolen M, Kearney P, Flygare J, Beckmann H, Weiszmann J, Lindstrom M, Walker N, Liu J, Biermann D, Wang Z, Hagiwara A, Iida T, Aramaki H, Kitao Y, Shinkai H, Furukawa N, Nishiu J, Nakamura M. Taygerly JP, et al. Among authors: thoolen m. Bioorg Med Chem. 2013 Feb 15;21(4):979-92. doi: 10.1016/j.bmc.2012.11.058. Epub 2012 Dec 10. Bioorg Med Chem. 2013. PMID: 23294830

8

Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier.

Rubenstein SM, Baichwal V, Beckmann H, Clark DL, Frankmoelle W, Roche D, Santha E, Schwender S, Thoolen M, Ye Q, Jaen JC. Rubenstein SM, et al. Among authors: thoolen m. J Med Chem. 2001 Oct 25;44(22):3599-605. doi: 10.1021/jm000478d. J Med Chem. 2001. PMID: 11606124

9

Ring constrained analogues of beta-alanine-containing GPIIb/IIIa receptor antagonists.

Sielecki TM, Wityak J, Liu J, Mousa SA, Thoolen M, Wexler RR, Olson RE. Sielecki TM, et al. Among authors: thoolen m. Bioorg Med Chem Lett. 2000 Mar 6;10(5):449-52. doi: 10.1016/s0960-894x(00)00023-8. Bioorg Med Chem Lett. 2000. PMID: 10743945

10

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.

Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR. Quan ML, et al. Among authors: thoolen mj. J Med Chem. 1999 Jul 29;42(15):2752-9. doi: 10.1021/jm980405i. J Med Chem. 1999. PMID: 10425086

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