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Page 1
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment.
Nat Cancer. 2022 Mar;3(3):318-336. doi: 10.1038/s43018-021-00326-1. Epub 2022 Jan 31.
Nat Cancer. 2022.
PMID: 35122074
Free PMC article.
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Öllinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, Götzfried J, Schuck K, Hassan Z, Arbeiter A, Schönhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Klöppel G, Cadiñanos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R.
Mueller S, et al. Among authors: kaltenbacher t.
Nature. 2018 Feb 1;554(7690):62-68. doi: 10.1038/nature25459. Epub 2018 Jan 24.
Nature. 2018.
PMID: 29364867
Free PMC article.
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In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Fischer A, Lersch R, de Andrade Krätzig N, Strong A, Friedrich MJ, Weber J, Engleitner T, Öllinger R, Yen HY, Kohlhofer U, Gonzalez-Menendez I, Sailer D, Kogan L, Lahnalampi M, Laukkanen S, Kaltenbacher T, Klement C, Rezaei M, Ammon T, Montero JJ, Schneider G, Mayerle J, Heikenwälder M, Schmidt-Supprian M, Quintanilla-Martinez L, Steiger K, Liu P, Cadiñanos J, Vassiliou GS, Saur D, Lohi O, Heinäniemi M, Conte N, Bradley A, Rad L, Rad R.
Fischer A, et al. Among authors: kaltenbacher t.
Cell Genom. 2023 Mar 8;3(3):100276. doi: 10.1016/j.xgen.2023.100276. eCollection 2023 Mar 8.
Cell Genom. 2023.
PMID: 36950387
Free PMC article.
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CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver.
Kaltenbacher T, Löprich J, Maresch R, Weber J, Müller S, Oellinger R, Groß N, Griger J, de Andrade Krätzig N, Avramopoulos P, Ramanujam D, Brummer S, Widholz SA, Bärthel S, Falcomatà C, Pfaus A, Alnatsha A, Mayerle J, Schmidt-Supprian M, Reichert M, Schneider G, Ehmer U, Braun CJ, Saur D, Engelhardt S, Rad R.
Kaltenbacher T, et al.
Nat Protoc. 2022 Apr;17(4):1142-1188. doi: 10.1038/s41596-021-00677-0. Epub 2022 Mar 14.
Nat Protoc. 2022.
PMID: 35288718
Review.
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Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state.
Götz V, Qiao S, Das D, Wartenberg P, Wyatt A, Wahl V, Gamayun I, Alasmi S, Fecher-Trost C, Meyer MR, Rad R, Kaltenbacher T, Kattler K, Lipp P, Becherer U, Mollard P, Candlish M, Boehm U.
Götz V, et al. Among authors: kaltenbacher t.
Cell Rep. 2023 Jun 27;42(6):112543. doi: 10.1016/j.celrep.2023.112543. Epub 2023 May 23.
Cell Rep. 2023.
PMID: 37224016
Free article.
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Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.
Catalano A, Adlesic M, Kaltenbacher T, Klar RFU, Albers J, Seidel P, Brandt LP, Hejhal T, Busenhart P, Röhner N, Zodel K, Fritsch K, Wild PJ, Duyster J, Fritsch R, Brummer T, Frew IJ.
Catalano A, et al. Among authors: kaltenbacher t.
Cancers (Basel). 2021 Apr 13;13(8):1852. doi: 10.3390/cancers13081852.
Cancers (Basel). 2021.
PMID: 33924486
Free PMC article.
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Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.
Köhler M, Röring M, Schorch B, Heilmann K, Stickel N, Fiala GJ, Schmitt LC, Braun S, Ehrenfeld S, Uhl FM, Kaltenbacher T, Weinberg F, Herzog S, Zeiser R, Schamel WW, Jumaa H, Brummer T.
Köhler M, et al. Among authors: kaltenbacher t.
EMBO J. 2016 Jan 18;35(2):143-61. doi: 10.15252/embj.201592097. Epub 2015 Dec 10.
EMBO J. 2016.
PMID: 26657898
Free PMC article.
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