Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.
Mackenzie AE, Quon T, Lin LC, Hauser AS, Jenkins L, Inoue A, Tobin AB, Gloriam DE, Hudson BD, Milligan G.
Mackenzie AE, et al. Among authors: tobin ab.
FASEB J. 2019 Apr;33(4):5005-5017. doi: 10.1096/fj.201801956R. Epub 2019 Jan 2.
FASEB J. 2019.
PMID: 30601679
Free PMC article.
These studies demonstrate that Galpha(13) is markedly the most effective G protein for interaction with GPR35 and that selection between Galpha(13) and Galpha(12) is dictated largely by a single conservative amino acid variation.-Mackenzie, A. E., Quon, T., Lin, L.- …
These studies demonstrate that Galpha(13) is markedly the most effective G protein for interaction with GPR35 and that selection between Gal …