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Activation of membrane-associated procaspase-3 is regulated by Bcl-2.
Krebs JF, Armstrong RC, Srinivasan A, Aja T, Wong AM, Aboy A, Sayers R, Pham B, Vu T, Hoang K, Karanewsky DS, Leist C, Schmitz A, Wu JC, Tomaselli KJ, Fritz LC. Krebs JF, et al. Among authors: tomaselli kj. J Cell Biol. 1999 Mar 8;144(5):915-26. doi: 10.1083/jcb.144.5.915. J Cell Biol. 1999. PMID: 10085291 Free PMC article.
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH. Oltersdorf T, et al. Among authors: tomaselli kj. Nature. 2005 Jun 2;435(7042):677-81. doi: 10.1038/nature03579. Epub 2005 May 15. Nature. 2005. PMID: 15902208 Free article.
Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP.
Zou H, Yang R, Hao J, Wang J, Sun C, Fesik SW, Wu JC, Tomaselli KJ, Armstrong RC. Zou H, et al. Among authors: tomaselli kj. J Biol Chem. 2003 Mar 7;278(10):8091-8. doi: 10.1074/jbc.M204783200. Epub 2002 Dec 27. J Biol Chem. 2003. PMID: 12506111 Free article.
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW. Oost TK, et al. Among authors: tomaselli kj. J Med Chem. 2004 Aug 26;47(18):4417-26. doi: 10.1021/jm040037k. J Med Chem. 2004. PMID: 15317454
67 results