Tominari Y - Search Results

1

The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice.

Yesbolatova A, Saito Y, Kitamoto N, Makino-Itou H, Ajima R, Nakano R, Nakaoka H, Fukui K, Gamo K, Tominari Y, Takeuchi H, Saga Y, Hayashi KI, Kanemaki MT. Yesbolatova A, et al. Among authors: tominari y. Nat Commun. 2020 Nov 11;11(1):5701. doi: 10.1038/s41467-020-19532-z. Nat Commun. 2020. PMID: 33177522 Free PMC article.

2

Ligand-induced genetic degradation as a tool for target validation.

Yesbolatova A, Tominari Y, Kanemaki MT. Yesbolatova A, et al. Among authors: tominari y. Drug Discov Today Technol. 2019 Apr;31:91-98. doi: 10.1016/j.ddtec.2018.11.001. Epub 2018 Nov 24. Drug Discov Today Technol. 2019. PMID: 31200864 Review.

3

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups.

Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Kan T, et al. Among authors: tominari y. Chem Commun (Camb). 2003 Sep 7;(17):2244-5. doi: 10.1039/b306970b. Chem Commun (Camb). 2003. PMID: 13678222

4

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.

Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Takahashi Y, et al. Among authors: tominari y. J Biol Chem. 2003 May 16;278(20):18664-70. doi: 10.1074/jbc.M301619200. Epub 2003 Mar 10. J Biol Chem. 2003. PMID: 12637581 Free article.

5

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.

Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Kan T, et al. Among authors: tominari y. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1983-5. doi: 10.1016/j.bmcl.2004.01.067. Bioorg Med Chem Lett. 2004. PMID: 15050642

6

Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.

Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Kan T, et al. Among authors: tominari y. Org Lett. 2007 May 24;9(11):2055-8. doi: 10.1021/ol070376i. Epub 2007 May 5. Org Lett. 2007. PMID: 17480083

7

C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).

Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. Morohashi Y, et al. Among authors: tominari y. J Biol Chem. 2006 May 26;281(21):14670-6. doi: 10.1074/jbc.M513012200. Epub 2006 Mar 28. J Biol Chem. 2006. PMID: 16569643 Free article.

8

Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

Hattori Y, Matsumoto S, Morimoto S, Daini M, Toyofuku M, Matsuda S, Baba R, Murakami K, Iwatani M, Oki H, Iwasaki S, Matsumiya K, Tominari Y, Kimura H, Ito M. Hattori Y, et al. Among authors: tominari y. Eur J Med Chem. 2022 Sep 5;239:114522. doi: 10.1016/j.ejmech.2022.114522. Epub 2022 Jun 7. Eur J Med Chem. 2022. PMID: 35749987 Free article.

9

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.

Shibata A, Kuno M, Adachi R, Sato Y, Hattori H, Matsuda A, Okuzono Y, Igaki K, Tominari Y, Takagi T, Yabuki M, Okaniwa M. Shibata A, et al. Among authors: tominari y. PLoS One. 2017 Oct 24;12(10):e0186587. doi: 10.1371/journal.pone.0186587. eCollection 2017. PLoS One. 2017. PMID: 29065190 Free PMC article.

10

D-band optical modulators using electro-optic polymer waveguides and non-coplanar patch antennas.

Kaji T, Morohashi I, Tominari Y, Ohara M, Yamada T, Otomo A. Kaji T, et al. Among authors: tominari y. Opt Express. 2023 May 22;31(11):17112-17121. doi: 10.1364/OE.484191. Opt Express. 2023. PMID: 37381453 Free article.

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