Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies

Hypertension. 2021 May 5;77(5):1559-1570. doi: 10.1161/HYPERTENSIONAHA.120.16808. Epub 2021 Mar 8.

Abstract

[Figure: see text].

Keywords: activin A; cardiomyopathy; endoglin; heart failure; hypertrophy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activins / genetics
  • Activins / metabolism
  • Animals
  • Cardiomegaly / genetics
  • Cardiomegaly / metabolism*
  • Cardiomegaly / physiopathology
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Gastrointestinal Hormones / genetics
  • Gastrointestinal Hormones / metabolism*
  • Heart Failure / genetics
  • Heart Failure / metabolism*
  • Heart Failure / physiopathology
  • Humans
  • Mice
  • Mice, Transgenic
  • Myocytes, Cardiac / metabolism*
  • Neuropeptides / genetics
  • Neuropeptides / metabolism*
  • Signal Transduction / physiology*

Substances

  • Gastrointestinal Hormones
  • Neuropeptides
  • Prok2 protein, mouse
  • activin A
  • Activins