Townsend CA - Search Results

1

Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad.

Buller AR, Townsend CA. Buller AR, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E653-61. doi: 10.1073/pnas.1221050110. Epub 2013 Feb 4. Proc Natl Acad Sci U S A. 2013. PMID: 23382230 Free PMC article.

2

beta-Lactam synthetase: a new biosynthetic enzyme.

Bachmann BO, Li R, Townsend CA. Bachmann BO, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9082-6. doi: 10.1073/pnas.95.16.9082. Proc Natl Acad Sci U S A. 1998. PMID: 9689037 Free PMC article.

3

Synthesis and antitumor activity of an inhibitor of fatty acid synthase.

Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, Townsend CA. Kuhajda FP, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3450-4. doi: 10.1073/pnas.97.7.3450. Proc Natl Acad Sci U S A. 2000. PMID: 10716717 Free PMC article.

4

Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase.

Crawford JM, Dancy BC, Hill EA, Udwary DW, Townsend CA. Crawford JM, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16728-33. doi: 10.1073/pnas.0604112103. Epub 2006 Oct 27. Proc Natl Acad Sci U S A. 2006. PMID: 17071746 Free PMC article.

5

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.

Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA. Freeman MF, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11128-33. doi: 10.1073/pnas.0804500105. Epub 2008 Aug 4. Proc Natl Acad Sci U S A. 2008. PMID: 18678912 Free PMC article.

6

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement.

Buller AR, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Buller AR, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2308-13. doi: 10.1073/pnas.1113633109. Epub 2012 Jan 30. Proc Natl Acad Sci U S A. 2012. PMID: 22308359 Free PMC article.

7

Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis.

Buller AR, Labonte JW, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Buller AR, et al. Among authors: townsend ca. J Mol Biol. 2012 Sep 28;422(4):508-18. doi: 10.1016/j.jmb.2012.06.012. Epub 2012 Jun 15. J Mol Biol. 2012. PMID: 22706025 Free PMC article.

8

Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.

Buller AR, Freeman MF, Schildbach JF, Townsend CA. Buller AR, et al. Among authors: townsend ca. Biochemistry. 2014 Jul 8;53(26):4273-81. doi: 10.1021/bi500385d. Epub 2014 Jun 26. Biochemistry. 2014. PMID: 24933323 Free PMC article.

9

Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis.

Marous DR, Lloyd EP, Buller AR, Moshos KA, Grove TL, Blaszczyk AJ, Booker SJ, Townsend CA. Marous DR, et al. Among authors: townsend ca. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10354-8. doi: 10.1073/pnas.1508615112. Epub 2015 Aug 3. Proc Natl Acad Sci U S A. 2015. PMID: 26240322 Free PMC article.

10

Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions.

Patel KD, d'Andrea FB, Gaudelli NM, Buller AR, Townsend CA, Gulick AM. Patel KD, et al. Among authors: townsend ca. Nat Commun. 2019 Aug 27;10(1):3868. doi: 10.1038/s41467-019-11740-6. Nat Commun. 2019. PMID: 31455765 Free PMC article.

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