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Page 1
IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity.
Nat Commun. 2024 Jan 2;15(1):89. doi: 10.1038/s41467-023-44310-y.
Nat Commun. 2024.
PMID: 38167707
Free PMC article.
Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding.
Zaman S, Yu X, Bencivenga AF, Blanden AR, Liu Y, Withers T, Na B, Blayney AJ, Gilleran J, Boothman DA, Loh SN, Kimball SD, Carpizo DR.
Zaman S, et al. Among authors: withers t.
Mol Cancer Ther. 2019 Aug;18(8):1355-1365. doi: 10.1158/1535-7163.MCT-18-1080. Epub 2019 Jun 13.
Mol Cancer Ther. 2019.
PMID: 31196889
Free PMC article.
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Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants.
Blanden AR, Yu X, Blayney AJ, Demas C, Ha JH, Liu Y, Withers T, Carpizo DR, Loh SN.
Blanden AR, et al. Among authors: withers t.
Elife. 2020 Dec 2;9:e61487. doi: 10.7554/eLife.61487.
Elife. 2020.
PMID: 33263541
Free PMC article.
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Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation.
Na B, Yu X, Withers T, Gilleran J, Yao M, Foo TK, Chen C, Moore D, Lin Y, Kimball SD, Xia B, Ganesan S, Carpizo DR.
Na B, et al. Among authors: withers t.
NPJ Breast Cancer. 2019 Apr 15;5:14. doi: 10.1038/s41523-019-0110-1. eCollection 2019.
NPJ Breast Cancer. 2019.
PMID: 30993195
Free PMC article.
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Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics.
Yu X, Kogan S, Chen Y, Tsang AT, Withers T, Lin H, Gilleran J, Buckley B, Moore D, Bertino J, Chan C, Kimball SD, Loh SN, Carpizo DR.
Yu X, et al. Among authors: withers t.
Clin Cancer Res. 2018 Sep 15;24(18):4505-4517. doi: 10.1158/1078-0432.CCR-18-0822. Epub 2018 Jun 18.
Clin Cancer Res. 2018.
PMID: 29914895
Free PMC article.
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