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Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase.
Edwards PD, Andisik DW, Bryant CA, Ewing B, Gomes B, Lewis JJ, Rakiewicz D, Steelman G, Strimpler A, Trainor DA, Tuthill PA, Mauger RC, Veale CA, Wildonger RA, Williams JC, Wolanin DJ, Zottola M. Edwards PD, et al. Among authors: trainor da. J Med Chem. 1997 Jun 6;40(12):1876-85. doi: 10.1021/jm960819g. J Med Chem. 1997. PMID: 9191965
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
Ohnmacht CJ, Russell K, Empfield JR, Frank CA, Gibson KH, Mayhugh DR, McLaren FM, Shapiro HS, Brown FJ, Trainor DA, Ceccarelli C, Lin MM, Masek BB, Forst JM, Harris RJ, Hulsizer JM, Lewis JJ, Silverman SM, Smith RW, Warwick PJ, Kau ST, Chun AL, Grant TL, Howe BB, Neilson KL, et al. Ohnmacht CJ, et al. Among authors: trainor da. J Med Chem. 1996 Nov 8;39(23):4592-601. doi: 10.1021/jm960365n. J Med Chem. 1996. PMID: 8917648
Calcium dependent K-channels in guinea pig and human urinary bladder.
Trivedi S, Potter-Lee L, Li JH, Yasay GD, Russell K, Ohnmacht CJ, Empfield JR, Trainor DA, Kau ST. Trivedi S, et al. Among authors: trainor da. Biochem Biophys Res Commun. 1995 Aug 15;213(2):404-9. doi: 10.1006/bbrc.1995.2146. Biochem Biophys Res Commun. 1995. PMID: 7544120
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