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An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer.
Br J Cancer. 2023 Apr;128(8):1592-1602. doi: 10.1038/s41416-023-02192-3. Epub 2023 Feb 9.
Br J Cancer. 2023.
PMID: 36759728
Free PMC article.
Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion.
Chatterjee T, Zhang S, Posey TA, Jacob J, Wu L, Yu W, Francisco LE, Liu QJ, Carmon KS.
Chatterjee T, et al.
J Biol Chem. 2021 Jan-Jun;296:100261. doi: 10.1016/j.jbc.2021.100261. Epub 2021 Jan 8.
J Biol Chem. 2021.
PMID: 33837725
Free PMC article.
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GPR56 Drives Colorectal Tumor Growth and Promotes Drug Resistance through Upregulation of MDR1 Expression via a RhoA-Mediated Mechanism.
Zhang S, Chatterjee T, Godoy C, Wu L, Liu QJ, Carmon KS.
Zhang S, et al. Among authors: chatterjee t.
Mol Cancer Res. 2019 Nov;17(11):2196-2207. doi: 10.1158/1541-7786.MCR-19-0436. Epub 2019 Aug 23.
Mol Cancer Res. 2019.
PMID: 31444231
Free PMC article.
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