Trenkle WC - Search Results

1

Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists.

Shinkre BA, Kumar TS, Gao ZG, Deflorian F, Jacobson KA, Trenkle WC. Shinkre BA, et al. Among authors: trenkle wc. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5690-4. doi: 10.1016/j.bmcl.2010.08.021. Epub 2010 Aug 10. Bioorg Med Chem Lett. 2010. PMID: 20801028 Free PMC article.

2

Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.

Kumar TS, Mishra S, Deflorian F, Yoo LS, Phan K, Kecskés M, Szabo A, Shinkre B, Gao ZG, Trenkle W, Jacobson KA. Kumar TS, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2740-5. doi: 10.1016/j.bmcl.2010.11.082. Epub 2010 Nov 21. Bioorg Med Chem Lett. 2011. PMID: 21185184 Free PMC article.

3

Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.

Bhattacharjee AK, Lang L, Jacobson O, Shinkre B, Ma Y, Niu G, Trenkle WC, Jacobson KA, Chen X, Kiesewetter DO. Bhattacharjee AK, et al. Among authors: trenkle wc. Nucl Med Biol. 2011 Aug;38(6):897-906. doi: 10.1016/j.nucmedbio.2011.01.009. Epub 2011 Mar 30. Nucl Med Biol. 2011. PMID: 21843786 Free PMC article.

4

The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group.

Wang Q, Shinkre BA, Lee JG, Weniger MA, Liu Y, Chen W, Wiestner A, Trenkle WC, Ye Y. Wang Q, et al. Among authors: trenkle wc. PLoS One. 2010 Nov 12;5(11):e15479. doi: 10.1371/journal.pone.0015479. PLoS One. 2010. PMID: 21124757 Free PMC article.

5

Synthesis and confirmation of the absolute stereochemistry of the (-)-aflastatin A C9-C27 degradation polyol.

Evans DA, Trenkle WC, Zhang J, Burch JD. Evans DA, et al. Among authors: trenkle wc. Org Lett. 2005 Jul 21;7(15):3335-8. doi: 10.1021/ol051225n. Org Lett. 2005. PMID: 16018654

6

A one-pot preparation of N-2-mercaptobenzoyl-amino amides.

Bahde RJ, Appella DH, Trenkle WC. Bahde RJ, et al. Among authors: trenkle wc. Tetrahedron Lett. 2011 Aug 10;52(32):4103-4105. doi: 10.1016/j.tetlet.2011.05.115. Tetrahedron Lett. 2011. PMID: 21931465 Free PMC article.

7

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.

Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y. Wang Q, et al. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2200-5. doi: 10.1073/pnas.0807611106. Epub 2009 Jan 22. Proc Natl Acad Sci U S A. 2009. PMID: 19164757 Free PMC article.

8

Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis.

Park SJ, Ahmad F, Bahde RJ, Philp A, Kim J, Huang T, Kim MK, Trenkle WC, Chung JH. Park SJ, et al. Among authors: trenkle wc. PLoS One. 2021 Jun 17;16(6):e0253269. doi: 10.1371/journal.pone.0253269. eCollection 2021. PLoS One. 2021. PMID: 34138962 Free PMC article.

9

Total Synthesis of Aflastatin A.

Evans DA, Beiger JJ, Burch JD, Fuller PH, Glorius F, Kattnig E, Thaisrivongs DA, Trenkle WC, Young JM, Zhang J. Evans DA, et al. Among authors: trenkle wc. J Am Chem Soc. 2022 Nov 2;144(43):19953-19972. doi: 10.1021/jacs.2c08244. Epub 2022 Oct 21. J Am Chem Soc. 2022. PMID: 36269121

10

Cytosine analogues from substituted acetonitriles via Thorpe condensation.

Barkin JL, Faust MD Jr, Trenkle WC. Barkin JL, et al. Among authors: trenkle wc. Org Lett. 2003 Sep 4;5(18):3333-5. doi: 10.1021/ol035223j. Org Lett. 2003. PMID: 12943420

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