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Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Prévot V. Duquenne M, et al. Among authors: trinquet e. Nat Metab. 2021 Aug;3(8):1071-1090. doi: 10.1038/s42255-021-00432-5. Epub 2021 Aug 2. Nat Metab. 2021. PMID: 34341568 Free PMC article.
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.
Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prévot V. Balland E, et al. Among authors: trinquet e. Cell Metab. 2014 Feb 4;19(2):293-301. doi: 10.1016/j.cmet.2013.12.015. Cell Metab. 2014. PMID: 24506870 Free PMC article.
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P. Schaeffer M, et al. Among authors: trinquet e. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7. doi: 10.1073/pnas.1212137110. Epub 2013 Jan 7. Proc Natl Acad Sci U S A. 2013. PMID: 23297228 Free PMC article.
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Scholler P, Moreno-Delgado D, Lecat-Guillet N, Doumazane E, Monnier C, Charrier-Savournin F, Fabre L, Chouvet C, Soldevila S, Lamarque L, Donsimoni G, Roux T, Zwier JM, Trinquet E, Rondard P, Pin JP. Scholler P, et al. Among authors: trinquet e. Nat Chem Biol. 2017 Apr;13(4):372-380. doi: 10.1038/nchembio.2286. Epub 2017 Jan 30. Nat Chem Biol. 2017. PMID: 28135236
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.
Rivat C, Sar C, Mechaly I, Leyris JP, Diouloufet L, Sonrier C, Philipson Y, Lucas O, Mallié S, Jouvenel A, Tassou A, Haton H, Venteo S, Pin JP, Trinquet E, Charrier-Savournin F, Mezghrani A, Joly W, Mion J, Schmitt M, Pattyn A, Marmigère F, Sokoloff P, Carroll P, Rognan D, Valmier J. Rivat C, et al. Among authors: trinquet e. Nat Commun. 2018 Mar 12;9(1):1042. doi: 10.1038/s41467-018-03496-2. Nat Commun. 2018. PMID: 29531216 Free PMC article.
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, Durroux T. Albizu L, et al. Among authors: trinquet e. Nat Chem Biol. 2010 Aug;6(8):587-94. doi: 10.1038/nchembio.396. Epub 2010 Jul 11. Nat Chem Biol. 2010. PMID: 20622858 Free PMC article.
65 results