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Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression.
Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Iovanna JL, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S. Gouirand V, et al. Among authors: gicquel t. EMBO J. 2022 May 2;41(9):e110466. doi: 10.15252/embj.2021110466. Epub 2022 Mar 21. EMBO J. 2022. PMID: 35307861 Free PMC article.
Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo.
Reyes-Castellanos G, Abdel Hadi N, Gallardo-Arriaga S, Masoud R, Garcia J, Lac S, El Kaoutari A, Gicquel T, Planque M, Fendt SM, Linares LK, Gayet O, Guillaumond F, Dusetti N, Iovanna J, Carrier A. Reyes-Castellanos G, et al. Among authors: gicquel t. iScience. 2023 May 19;26(6):106899. doi: 10.1016/j.isci.2023.106899. eCollection 2023 Jun 16. iScience. 2023. PMID: 37305702 Free PMC article.
Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer.
Masoud R, Reyes-Castellanos G, Lac S, Garcia J, Dou S, Shintu L, Abdel Hadi N, Gicquel T, El Kaoutari A, Diémé B, Tranchida F, Cormareche L, Borge L, Gayet O, Pasquier E, Dusetti N, Iovanna J, Carrier A. Masoud R, et al. Among authors: gicquel t. Cell Rep Med. 2020 Nov 17;1(8):100143. doi: 10.1016/j.xcrm.2020.100143. eCollection 2020 Nov 17. Cell Rep Med. 2020. PMID: 33294863 Free PMC article.
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F, Vander Heiden MG, Vasseur S. Olivares O, et al. Among authors: gicquel t. Nat Commun. 2017 Jul 7;8:16031. doi: 10.1038/ncomms16031. Nat Commun. 2017. PMID: 28685754 Free PMC article.