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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Cell. 2023 May 25;186(11):2361-2379.e25. doi: 10.1016/j.cell.2023.04.026. Epub 2023 May 15.
Cell. 2023.
PMID: 37192619
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.
Weiss-Sadan T, et al. Among authors: vornbaumen t.
Cell Metab. 2023 Mar 7;35(3):487-503.e7. doi: 10.1016/j.cmet.2023.01.012. Epub 2023 Feb 24.
Cell Metab. 2023.
PMID: 36841242
Free PMC article.
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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.
Weiss-Sadan T, et al. Among authors: vornbaumen t.
Cell Metab. 2023 Apr 4;35(4):722. doi: 10.1016/j.cmet.2023.03.011.
Cell Metab. 2023.
PMID: 37019082
Free PMC article.
No abstract available.
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Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway.
Zhang J, Simpson CM, Berner J, Chong HB, Fang J, Sahin ZO, Weiss-Sadan T, Possemato AP, Harry S, Takahashi M, Yang TY, Richter M, Patel H, Smith AE, Carlin AD, Hubertus de Groot AF, Wolf K, Shi L, Wei TY, Dürr BR, Chen NJ, Vornbäumen T, Wichmann NO, Pooladanda V, Matoba Y, Kumar S, Kim E, Bouberhan S, Olivia E, Rueda B, Bardeesy N, Liau B, Lawrence M, Stokes MP, Beausoleil SA, Bar-Peled L.
Zhang J, et al. Among authors: vornbaumen t.
bioRxiv [Preprint]. 2023 Mar 11:2023.03.11.532189. doi: 10.1101/2023.03.11.532189.
bioRxiv. 2023.
PMID: 36945474
Free PMC article.
Updated.
Preprint.
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A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.
Wit N, Gogola E, West JA, Vornbäumen T, Seear RV, Bailey PSJ, Burgos-Barragan G, Wang M, Krawczyk P, Huberts DHEW, Gergely F, Matheson NJ, Kaser A, Nathan JA, Patel KJ.
Wit N, et al. Among authors: vornbaumen t.
Sci Adv. 2023 May 19;9(20):eadg2235. doi: 10.1126/sciadv.adg2235. Epub 2023 May 17.
Sci Adv. 2023.
PMID: 37196082
Free PMC article.
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