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Page 1
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Sadik A, Somarribas Patterson LF, Öztürk S, Mohapatra SR, Panitz V, Secker PF, Pfänder P, Loth S, Salem H, Prentzell MT, Berdel B, Iskar M, Faessler E, Reuter F, Kirst I, Kalter V, Foerster KI, Jäger E, Guevara CR, Sobeh M, Hielscher T, Poschet G, Reinhardt A, Hassel JC, Zapatka M, Hahn U, von Deimling A, Hopf C, Schlichting R, Escher BI, Burhenne J, Haefeli WE, Ishaque N, Böhme A, Schäuble S, Thedieck K, Trump S, Seiffert M, Opitz CA. Sadik A, et al. Among authors: trump s. Cell. 2020 Sep 3;182(5):1252-1270.e34. doi: 10.1016/j.cell.2020.07.038. Epub 2020 Aug 19. Cell. 2020. PMID: 32818467 Free article.
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M. Opitz CA, et al. Among authors: trump s. Nature. 2011 Oct 5;478(7368):197-203. doi: 10.1038/nature10491. Nature. 2011. PMID: 21976023 Free article.
Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Litzenburger UM, Opitz CA, Sahm F, Rauschenbach KJ, Trump S, Winter M, Ott M, Ochs K, Lutz C, Liu X, Anastasov N, Lehmann I, Höfer T, von Deimling A, Wick W, Platten M. Litzenburger UM, et al. Among authors: trump s. Oncotarget. 2014 Feb 28;5(4):1038-51. doi: 10.18632/oncotarget.1637. Oncotarget. 2014. PMID: 24657910 Free PMC article.
Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.
Dewi DL, Mohapatra SR, Blanco Cabañes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thürmann L, Loth S, Heilmann K, Weichenhan D, Mücke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner KH, Schott S, Plass C, Platten M, Gerhäuser C, Trump S, Opitz CA. Dewi DL, et al. Among authors: trump s. Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017. Oncoimmunology. 2017. PMID: 28344890 Free PMC article.
Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.
Adam I, Dewi DL, Mooiweer J, Sadik A, Mohapatra SR, Berdel B, Keil M, Sonner JK, Thedieck K, Rose AJ, Platten M, Heiland I, Trump S, Opitz CA. Adam I, et al. Among authors: trump s. Oncoimmunology. 2018 Sep 5;7(12):e1486353. doi: 10.1080/2162402X.2018.1486353. eCollection 2018. Oncoimmunology. 2018. PMID: 30524887 Free PMC article.
The therapeutic potential of targeting tryptophan catabolism in cancer.
Opitz CA, Somarribas Patterson LF, Mohapatra SR, Dewi DL, Sadik A, Platten M, Trump S. Opitz CA, et al. Among authors: trump s. Br J Cancer. 2020 Jan;122(1):30-44. doi: 10.1038/s41416-019-0664-6. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819194 Free PMC article. Review.
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: trump s. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA. Panitz V, et al. Among authors: trump s. Theranostics. 2021 Sep 3;11(19):9217-9233. doi: 10.7150/thno.60679. eCollection 2021. Theranostics. 2021. PMID: 34646367 Free PMC article.
Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions.
Thürmann L, Klös M, Mackowiak SD, Bieg M, Bauer T, Ishaque N, Messingschlager M, Herrmann C, Röder S, Bauer M, Schäuble S, Faessler E, Hahn U, Weichenhan D, Mücke O, Plass C, Borte M, von Mutius E, Stangl GI, Lauener R, Karvonen AM, Divaret-Chauveau A, Riedler J, Heinrich J, Standl M, von Berg A, Schaaf B, Herberth G, Kabesch M, Eils R, Trump S, Lehmann I. Thürmann L, et al. Among authors: trump s. Allergy. 2023 Jun;78(6):1489-1506. doi: 10.1111/all.15658. Epub 2023 Feb 10. Allergy. 2023. PMID: 36704932
61 results