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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC. McNeela EA, et al. Among authors: tschopp j. PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191. PLoS Pathog. 2010. PMID: 21085613 Free PMC article.
The inflammasome.
Petrilli V, Papin S, Tschopp J. Petrilli V, et al. Among authors: tschopp j. Curr Biol. 2005 Aug 9;15(15):R581. doi: 10.1016/j.cub.2005.07.049. Curr Biol. 2005. PMID: 16085473 Free article. Review. No abstract available.
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
Sharp FA, Ruane D, Claass B, Creagh E, Harris J, Malyala P, Singh M, O'Hagan DT, Pétrilli V, Tschopp J, O'Neill LA, Lavelle EC. Sharp FA, et al. Among authors: tschopp j. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5. doi: 10.1073/pnas.0804897106. Epub 2009 Jan 12. Proc Natl Acad Sci U S A. 2009. PMID: 19139407 Free PMC article.
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Harris J, et al. Among authors: tschopp j. J Biol Chem. 2011 Mar 18;286(11):9587-97. doi: 10.1074/jbc.M110.202911. Epub 2011 Jan 12. J Biol Chem. 2011. PMID: 21228274 Free PMC article.
The role of potassium in inflammasome activation by bacteria.
Arlehamn CS, Pétrilli V, Gross O, Tschopp J, Evans TJ. Arlehamn CS, et al. Among authors: tschopp j. J Biol Chem. 2010 Apr 2;285(14):10508-18. doi: 10.1074/jbc.M109.067298. Epub 2010 Jan 22. J Biol Chem. 2010. PMID: 20097760 Free PMC article.
622 results