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Two-tiered enforcement of high-fidelity DNA ligation.
Nat Commun. 2019 Nov 28;10(1):5431. doi: 10.1038/s41467-019-13478-7.
Nat Commun. 2019.
PMID: 31780661
Free PMC article.
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.
Schellenberg MJ, Tumbale PP, Williams RS.
Schellenberg MJ, et al. Among authors: tumbale pp.
Prog Biophys Mol Biol. 2015 Mar;117(2-3):157-165. doi: 10.1016/j.pbiomolbio.2015.01.007. Epub 2015 Jan 29.
Prog Biophys Mol Biol. 2015.
PMID: 25637650
Free PMC article.
Review.
Item in Clipboard
Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
Fleming MC, Chiou LF, Tumbale PP, Droby GN, Lim J, Norris-Drouin JL, Williams JG, Pearce KH, Williams RS, Vaziri C, Bowers AA.
Fleming MC, et al. Among authors: tumbale pp.
J Med Chem. 2022 May 26;65(10):7231-7245. doi: 10.1021/acs.jmedchem.2c00185. Epub 2022 May 6.
J Med Chem. 2022.
PMID: 35522528
Free PMC article.
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High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
Williams JS, Tumbale PP, Arana ME, Rana JA, Williams RS, Kunkel TA.
Williams JS, et al. Among authors: tumbale pp.
Nat Commun. 2021 Jan 20;12(1):482. doi: 10.1038/s41467-020-20800-1.
Nat Commun. 2021.
PMID: 33473124
Free PMC article.
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LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.
Jurkiw TJ, Tumbale PP, Schellenberg MJ, Cunningham-Rundles C, Williams RS, O'Brien PJ.
Jurkiw TJ, et al. Among authors: tumbale pp.
Nucleic Acids Res. 2021 Feb 22;49(3):1619-1630. doi: 10.1093/nar/gkaa1297.
Nucleic Acids Res. 2021.
PMID: 33444456
Free PMC article.
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Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Kaminski AM, Tumbale PP, Schellenberg MJ, Williams RS, Williams JG, Kunkel TA, Pedersen LC, Bebenek K.
Kaminski AM, et al. Among authors: tumbale pp.
Nat Commun. 2018 Jul 6;9(1):2642. doi: 10.1038/s41467-018-05024-8.
Nat Commun. 2018.
PMID: 29980672
Free PMC article.
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