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E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F. Huang H, et al. Among authors: tyers m. Nat Chem Biol. 2014 Feb;10(2):156-163. doi: 10.1038/nchembio.1412. Epub 2013 Dec 15. Nat Chem Biol. 2014. PMID: 24316736 Free PMC article.
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.
St-Cyr D, Ceccarelli DF, Orlicky S, van der Sloot AM, Tang X, Kelso S, Moore S, James C, Posternak G, Coulombe-Huntington J, Bertomeu T, Marinier A, Sicheri F, Tyers M. St-Cyr D, et al. Among authors: tyers m. Sci Adv. 2021 Oct 29;7(44):eabi5797. doi: 10.1126/sciadv.abi5797. Epub 2021 Oct 27. Sci Adv. 2021. PMID: 34705497 Free PMC article.
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
Chana CK, Maisonneuve P, Posternak G, Grinberg NGA, Poirson J, Ona SM, Ceccarelli DF, Mader P, St-Cyr DJ, Pau V, Kurinov I, Tang X, Deng D, Cui W, Su W, Kuai L, Soll R, Tyers M, Röst HL, Batey RA, Taipale M, Gingras AC, Sicheri F. Chana CK, et al. Among authors: tyers m. J Med Chem. 2022 Oct 13;65(19):12725-12746. doi: 10.1021/acs.jmedchem.2c00509. Epub 2022 Sep 18. J Med Chem. 2022. PMID: 36117290 Free PMC article.
BoxPlotR: a web tool for generation of box plots.
Spitzer M, Wildenhain J, Rappsilber J, Tyers M. Spitzer M, et al. Among authors: tyers m. Nat Methods. 2014 Feb;11(2):121-2. doi: 10.1038/nmeth.2811. Nat Methods. 2014. PMID: 24481215 Free PMC article. No abstract available.
338 results