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Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
J Med Chem. 2011 Jun 9;54(11):3935-49. doi: 10.1021/jm200265b. Epub 2011 May 12.
J Med Chem. 2011.
PMID: 21517059
Free PMC article.
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
Gujjar R, Marwaha A, El Mazouni F, White J, White KL, Creason S, Shackleford DM, Baldwin J, Charman WN, Buckner FS, Charman S, Rathod PK, Phillips MA.
Gujjar R, et al.
J Med Chem. 2009 Apr 9;52(7):1864-72. doi: 10.1021/jm801343r.
J Med Chem. 2009.
PMID: 19296651
Free PMC article.
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