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Year Number of Results
2015 4
2016 6
2017 4
2018 2
2019 1
2024 0

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17 results

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Page 1
An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking.
Kozlitina J, Risso D, Lansu K, Olsen RHJ, Sainz E, Luiselli D, Barik A, Frigerio-Domingues C, Pagani L, Wooding S, Kirchner T, Niaura R, Roth B, Drayna D. Kozlitina J, et al. PLoS Genet. 2019 Feb 15;15(2):e1007916. doi: 10.1371/journal.pgen.1007916. eCollection 2019 Feb. PLoS Genet. 2019. PMID: 30768591 Free PMC article.
Unexplored therapeutic opportunities in the human genome.
Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma'ayan A, Malovannaya A, Mani S, Mathias SL, McManus MT, Meehan TF, von Mering C, Muthas D, Nguyen DT, Overington JP, Papadatos G, Qin J, Reich C, Roth BL, Schürer SC, Simeonov A, Sklar LA, Southall N, Tomita S, Tudose I, Ursu O, Vidovic D, Waller A, Westergaard D, Yang JJ, Zahoránszky-Köhalmi G. Oprea TI, et al. Nat Rev Drug Discov. 2018 May;17(5):317-332. doi: 10.1038/nrd.2018.14. Epub 2018 Mar 23. Nat Rev Drug Discov. 2018. PMID: 29472638 Free PMC article. Review.
Discovery of new GPCR ligands to illuminate new biology.
Roth BL, Irwin JJ, Shoichet BK. Roth BL, et al. Nat Chem Biol. 2017 Nov;13(11):1143-1151. doi: 10.1038/nchembio.2490. Epub 2017 Oct 18. Nat Chem Biol. 2017. PMID: 29045379 Free PMC article.
Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr, Benovic JL, An SS, Dulin NO, Penn RB. Pera T, et al. FASEB J. 2018 Feb;32(2):862-874. doi: 10.1096/fj.201700555R. Epub 2018 Jan 4. FASEB J. 2018. PMID: 29042451 Free PMC article.
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL. Lansu K, et al. Nat Chem Biol. 2017 May;13(5):529-536. doi: 10.1038/nchembio.2334. Epub 2017 Mar 13. Nat Chem Biol. 2017. PMID: 28288109 Free PMC article.
Structure-based discovery of opioid analgesics with reduced side effects.
Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Manglik A, et al. Nature. 2016 Sep 8;537(7619):185-190. doi: 10.1038/nature19112. Epub 2016 Aug 17. Nature. 2016. PMID: 27533032 Free PMC article.
17 results