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Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.
Wu JS, Lin SY, Liao FY, Hsiao WC, Lee LC, Peng YH, Hsieh CL, Wu MH, Song JS, Yueh A, Chen CH, Yeh SH, Liu CY, Lin SY, Yeh TK, Hsu JT, Shih C, Ueng SH, Hung MS, Wu SY. Wu JS, et al. Among authors: ueng sh. J Med Chem. 2015 Oct 8;58(19):7807-19. doi: 10.1021/acs.jmedchem.5b00921. Epub 2015 Sep 16. J Med Chem. 2015. PMID: 26348881
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.
Chen SR, Ke YY, Yeh TK, Lin SY, Ou LC, Chen SC, Chang WT, Chang HF, Wu ZH, Hsieh CC, Law PY, Loh HH, Shih C, Lai YK, Yeh SH, Ueng SH. Chen SR, et al. Among authors: ueng sh. Eur J Med Chem. 2017 Jan 27;126:202-217. doi: 10.1016/j.ejmech.2016.09.003. Epub 2016 Sep 20. Eur J Med Chem. 2017. PMID: 27776274
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.
Chao PK, Ueng SH, Ou LC, Yeh TK, Chang WT, Chang HF, Chen SC, Tao PL, Law PY, Loh HH, Cheng MF, Chuang JY, Chen CT, Shih C, Yeh SH. Chao PK, et al. Among authors: ueng sh. Anesthesiology. 2017 May;126(5):952-966. doi: 10.1097/ALN.0000000000001568. Anesthesiology. 2017. PMID: 28212204 Free article.
The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.
Lin SY, Kuo YH, Tien YW, Ke YY, Chang WT, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: ueng sh. Eur J Med Chem. 2019 Apr 1;167:312-323. doi: 10.1016/j.ejmech.2019.01.063. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30776693
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
Lin SY, Tien YW, Ke YY, Chang YC, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH. Lin SY, et al. Among authors: ueng sh. Bioorg Chem. 2022 Nov;128:105905. doi: 10.1016/j.bioorg.2022.105905. Epub 2022 Jun 2. Bioorg Chem. 2022. PMID: 35710525
125 results