Upton N - Search Results

1

Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat.

Smith MI, Piper DC, Duxon MS, Upton N. Smith MI, et al. Among authors: upton n. Neurosci Lett. 2003 May 8;341(3):256-8. doi: 10.1016/s0304-3940(03)00066-1. Neurosci Lett. 2003. PMID: 12697296

2

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N. Hagan JJ, et al. Among authors: upton n. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10911-6. doi: 10.1073/pnas.96.19.10911. Proc Natl Acad Sci U S A. 1999. PMID: 10485925 Free PMC article.

3

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.

Piper DC, Upton N, Smith MI, Hunter AJ. Piper DC, et al. Among authors: upton n. Eur J Neurosci. 2000 Feb;12(2):726-30. doi: 10.1046/j.1460-9568.2000.00919.x. Eur J Neurosci. 2000. PMID: 10712652

4

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.

Duxon MS, Stretton J, Starr K, Jones DN, Holland V, Riley G, Jerman J, Brough S, Smart D, Johns A, Chan W, Porter RA, Upton N. Duxon MS, et al. Among authors: upton n. Psychopharmacology (Berl). 2001 Jan 1;153(2):203-9. doi: 10.1007/s002130000550. Psychopharmacology (Berl). 2001. PMID: 11205420

5

SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.

Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR, Upton N, Porter RA, Johns A, Blundell JE. Rodgers RJ, et al. Among authors: upton n. Eur J Neurosci. 2001 Apr;13(7):1444-52. doi: 10.1046/j.0953-816x.2001.01518.x. Eur J Neurosci. 2001. PMID: 11298806

6

Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine.

Smith MI, Piper DC, Duxon MS, Upton N. Smith MI, et al. Among authors: upton n. Pharmacol Biochem Behav. 2002 Apr;71(4):599-605. doi: 10.1016/s0091-3057(01)00702-x. Pharmacol Biochem Behav. 2002. PMID: 11888551

7

LABORAS: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour.

Quinn LP, Stean TO, Trail B, Duxon MS, Stratton SC, Billinton A, Upton N. Quinn LP, et al. Among authors: upton n. J Neurosci Methods. 2003 Nov 30;130(1):83-92. doi: 10.1016/s0165-0270(03)00227-9. J Neurosci Methods. 2003. PMID: 14583407

8

SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.

Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. Starr KR, et al. Among authors: upton n. Neuropsychopharmacology. 2007 Oct;32(10):2163-72. doi: 10.1038/sj.npp.1301341. Epub 2007 Mar 14. Neuropsychopharmacology. 2007. PMID: 17356576

9

Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.

Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smith MI, Upton N, Medhurst AD, Middlemiss DN, Riley GJ, Lovell PJ, Bromidge SM, Thomas DR. Hagan JJ, et al. Among authors: upton n. Br J Pharmacol. 2000 Jun;130(3):539-48. doi: 10.1038/sj.bjp.0703357. Br J Pharmacol. 2000. PMID: 10821781 Free PMC article.

10

Latency to paroxetine-induced anxiolysis in the rat is reduced by co-administration of the 5-HT(1A) receptor antagonist WAY100635.

Duxon MS, Starr KR, Upton N. Duxon MS, et al. Among authors: upton n. Br J Pharmacol. 2000 Aug;130(7):1713-9. doi: 10.1038/sj.bjp.0703496. Br J Pharmacol. 2000. PMID: 10928979 Free PMC article.

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