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Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.
Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45. doi: 10.1016/j.bmcl.2011.09.049. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21982495 Free PMC article.
SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists.
Guerrero M, Urbano M, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Among authors: urbano m. Bioorg Med Chem Lett. 2013 Feb 1;23(3):614-9. doi: 10.1016/j.bmcl.2012.12.030. Epub 2012 Dec 20. Bioorg Med Chem Lett. 2013. PMID: 23287738 Free PMC article.
Modulators of the Sphingosine 1-phosphate receptor 1.
Urbano M, Guerrero M, Rosen H, Roberts E. Urbano M, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6377-89. doi: 10.1016/j.bmcl.2013.09.058. Epub 2013 Sep 29. Bioorg Med Chem Lett. 2013. PMID: 24125884 Free PMC article. Review.
Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.
Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Among authors: urbano m. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. doi: 10.1016/j.bmcl.2013.09.075. Epub 2013 Oct 1. Bioorg Med Chem Lett. 2013. PMID: 24135724 Free PMC article.
Antagonists of the kappa opioid receptor.
Urbano M, Guerrero M, Rosen H, Roberts E. Urbano M, et al. Bioorg Med Chem Lett. 2014 May 1;24(9):2021-32. doi: 10.1016/j.bmcl.2014.03.040. Epub 2014 Mar 24. Bioorg Med Chem Lett. 2014. PMID: 24690494 Review.
270 results