Uwamizu A - Search Results

1

Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.

Kawanabe-Matsuda H, Takeda K, Nakamura M, Makino S, Karasaki T, Kakimi K, Nishimukai M, Ohno T, Omi J, Kano K, Uwamizu A, Yagita H, Boneca IG, Eberl G, Aoki J, Smyth MJ, Okumura K. Kawanabe-Matsuda H, et al. Among authors: uwamizu a. Cancer Discov. 2022 May 2;12(5):1336-1355. doi: 10.1158/2159-8290.CD-21-0929. Cancer Discov. 2022. PMID: 35180303 Free PMC article.

2

Novel lysophosphoplipid receptors: their structure and function.

Makide K, Uwamizu A, Shinjo Y, Ishiguro J, Okutani M, Inoue A, Aoki J. Makide K, et al. Among authors: uwamizu a. J Lipid Res. 2014 Oct;55(10):1986-95. doi: 10.1194/jlr.R046920. Epub 2014 Jun 2. J Lipid Res. 2014. PMID: 24891334 Free PMC article. Review.

3

Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174.

Ikubo M, Inoue A, Nakamura S, Jung S, Sayama M, Otani Y, Uwamizu A, Suzuki K, Kishi T, Shuto A, Ishiguro J, Okudaira M, Kano K, Makide K, Aoki J, Ohwada T. Ikubo M, et al. Among authors: uwamizu a. J Med Chem. 2015 May 28;58(10):4204-19. doi: 10.1021/jm5020082. Epub 2015 May 13. J Med Chem. 2015. PMID: 25970039

4

Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.

Jung S, Inoue A, Nakamura S, Kishi T, Uwamizu A, Sayama M, Ikubo M, Otani Y, Kano K, Makide K, Aoki J, Ohwada T. Jung S, et al. Among authors: uwamizu a. J Med Chem. 2016 Apr 28;59(8):3750-76. doi: 10.1021/acs.jmedchem.5b01925. Epub 2016 Apr 14. J Med Chem. 2016. PMID: 27077565

5

Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.

Sayama M, Uwamizu A, Otani Y, Inoue A, Aoki J, Sekijima M, Ohwada T. Sayama M, et al. Among authors: uwamizu a. Biochemistry. 2020 Mar 24;59(11):1173-1201. doi: 10.1021/acs.biochem.0c00061. Epub 2020 Mar 10. Biochemistry. 2020. PMID: 32124599

6

Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors.

Nakamura S, Sayama M, Uwamizu A, Jung S, Ikubo M, Otani Y, Kano K, Omi J, Inoue A, Aoki J, Ohwada T. Nakamura S, et al. Among authors: uwamizu a. J Med Chem. 2020 Sep 10;63(17):9990-10029. doi: 10.1021/acs.jmedchem.0c01126. Epub 2020 Aug 24. J Med Chem. 2020. PMID: 32787112

7

Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.

Sayama M, Uwamizu A, Ikubo M, Chen L, Yan G, Otani Y, Inoue A, Aoki J, Ohwada T. Sayama M, et al. Among authors: uwamizu a. J Med Chem. 2021 Jul 22;64(14):10059-10101. doi: 10.1021/acs.jmedchem.1c00347. Epub 2021 Jul 7. J Med Chem. 2021. PMID: 34233115

8

Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.

Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, Kawakami K, Aoki J, Inoue A. Tatsumi M, et al. Among authors: uwamizu a. PLoS One. 2023 Jan 20;18(1):e0280448. doi: 10.1371/journal.pone.0280448. eCollection 2023. PLoS One. 2023. PMID: 36668668 Free PMC article.

9

Exploration of LPS₂ agonist binding modes using the combination of a new hydrophobic scaffold and homology modeling.

Chen L, Uwamizu A, Sayama M, Kano K, Otani Y, Kondo S, Inoue A, Aoki J, Ohwada T. Chen L, et al. Among authors: uwamizu a. Eur J Med Chem. 2023 Apr 5;252:115271. doi: 10.1016/j.ejmech.2023.115271. Epub 2023 Mar 11. Eur J Med Chem. 2023. PMID: 36965226

10

Emerging roles of lysophosphatidylserine as an immune modulator.

Yaginuma S, Omi J, Uwamizu A, Aoki J. Yaginuma S, et al. Among authors: uwamizu a. Immunol Rev. 2023 Aug;317(1):20-29. doi: 10.1111/imr.13204. Epub 2023 Apr 10. Immunol Rev. 2023. PMID: 37036835 Review.

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