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Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle.
McNally BD, Ashley DF, Hänschke L, Daou HN, Watt NT, Murfitt SA, MacCannell ADV, Whitehead A, Bowen TS, Sanders FWB, Vacca M, Witte KK, Davies GR, Bauer R, Griffin JL, Roberts LD. McNally BD, et al. Among authors: vacca m. Nat Commun. 2022 Apr 1;13(1):1748. doi: 10.1038/s41467-022-29363-9. Nat Commun. 2022. PMID: 35365625 Free PMC article.
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Hall Z, Oakley F, Vacca M, Griffin JL. Hall Z, et al. Among authors: vacca m. Hepatology. 2022 May;75(5):1347-1348. doi: 10.1002/hep.32365. Epub 2022 Feb 11. Hepatology. 2022. PMID: 35080268 No abstract available.
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.
Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Sanders FWB, et al. Among authors: vacca m. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. Genome Biol. 2018. PMID: 29925420 Free PMC article.
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Vacca M, et al. Nat Metab. 2020 Jun;2(6):514-531. doi: 10.1038/s42255-020-0214-9. Epub 2020 Jun 8. Nat Metab. 2020. PMID: 32694734
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Azzu V, et al. Among authors: vacca m. Mol Metab. 2021 Jun;48:101210. doi: 10.1016/j.molmet.2021.101210. Epub 2021 Mar 17. Mol Metab. 2021. PMID: 33722690 Free PMC article.
Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease.
Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hall Z, et al. Among authors: vacca m. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. Hepatology. 2017. PMID: 27863448 Free PMC article.
Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL. Hall Z, et al. Among authors: vacca m. Hepatology. 2021 Mar;73(3):1028-1044. doi: 10.1002/hep.31391. Epub 2020 Nov 3. Hepatology. 2021. PMID: 32460431
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Belenguer G, Mastrogiovanni G, Pacini C, Hall Z, Dowbaj AM, Arnes-Benito R, Sljukic A, Prior N, Kakava S, Bradshaw CR, Davies S, Vacca M, Saeb-Parsy K, Koo BK, Huch M. Belenguer G, et al. Among authors: vacca m. Nat Commun. 2022 Jan 17;13(1):334. doi: 10.1038/s41467-021-27923-z. Nat Commun. 2022. PMID: 35039505 Free PMC article.
Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome.
Mocciaro G, D'Amore S, Jenkins B, Kay R, Murgia A, Herrera-Marcos LV, Neun S, Sowton AP, Hall Z, Palma-Duran SA, Palasciano G, Reimann F, Murray A, Suppressa P, Sabbà C, Moschetta A, Koulman A, Griffin JL, Vacca M. Mocciaro G, et al. Among authors: vacca m. Int J Mol Sci. 2022 Jun 17;23(12):6786. doi: 10.3390/ijms23126786. Int J Mol Sci. 2022. PMID: 35743227 Free PMC article.
343 results