Vaidya CM - Search Results

1

Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523).

Vaidya CM, Wright JE, Rosowsky A. Vaidya CM, et al. J Med Chem. 2002 Apr 11;45(8):1690-6. doi: 10.1021/jm010518t. J Med Chem. 2002. PMID: 11931624

2

Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.

Rosowsky A, Vaidya CM, Bader H, Wright JE, Teicher BA. Rosowsky A, et al. Among authors: vaidya cm. J Med Chem. 1997 Jan 31;40(3):286-99. doi: 10.1021/jm9606453. J Med Chem. 1997. PMID: 9022795

3

Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).

Rosowsky A, Wright JE, Vaidya CM, Bader H, Forsch RA, Mota CE, Pardo J, Chen CS, Chen YN. Rosowsky A, et al. Among authors: vaidya cm. J Med Chem. 1998 Dec 17;41(26):5310-9. doi: 10.1021/jm980477+. J Med Chem. 1998. PMID: 9857098

4

The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.

Rosowsky A, Wright JE, Vaidya CM, Forsch RA. Rosowsky A, et al. Among authors: vaidya cm. Pharmacol Ther. 2000 Mar;85(3):191-205. doi: 10.1016/s0163-7258(99)00055-8. Pharmacol Ther. 2000. PMID: 10739874

5

Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.

Rosowsky A, Wright JE, Vaidya CM, Forsch RA, Bader H. Rosowsky A, et al. Among authors: vaidya cm. J Med Chem. 2000 Apr 20;43(8):1620-34. doi: 10.1021/jm990630f. J Med Chem. 2000. PMID: 10780919

6

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues.

Wright JE, Vaidya CM, Chen Y, Rosowsky A. Wright JE, et al. Among authors: vaidya cm. Biochem Pharmacol. 2000 Jul 1;60(1):41-6. doi: 10.1016/s0006-2952(00)00294-x. Biochem Pharmacol. 2000. PMID: 10807943

7

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

Abdullah L, Emiliani FE, Vaidya CM, Stuart H, Kolling FW, Ackerman ME, Song L, McKenna A, Huang YH. Abdullah L, et al. Among authors: vaidya cm. bioRxiv [Preprint]. 2024 Mar 27:2024.03.21.586160. doi: 10.1101/2024.03.21.586160. bioRxiv. 2024. PMID: 38585810 Free PMC article. Preprint.

8

Thromboxane A2/prostaglandin H2 receptor antagonists.

Le Breton GC, Lim CT, Vaidya CM, Venton DL. Le Breton GC, et al. Among authors: vaidya cm. Methods Enzymol. 1990;187:406-14. doi: 10.1016/0076-6879(90)87047-7. Methods Enzymol. 1990. PMID: 2146463 No abstract available.

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