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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. doi: 10.1016/j.bmcl.2008.10.054. Epub 2008 Oct 15.
Bioorg Med Chem Lett. 2008.
PMID: 18952427
A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.
Wang Y, Van Becelaere K, Jiang P, Przybranowski S, Omer C, Sebolt-Leopold J.
Wang Y, et al. Among authors: van becelaere k.
Neoplasia. 2005 Apr;7(4):336-47. doi: 10.1593/neo.04532.
Neoplasia. 2005.
PMID: 15967111
Free PMC article.
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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.
Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S, Leopold WR, Saltiel AR.
Sebolt-Leopold JS, et al. Among authors: van becelaere k.
Nat Med. 1999 Jul;5(7):810-6. doi: 10.1038/10533.
Nat Med. 1999.
PMID: 10395327
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Biomarker assays for phosphorylated MAP kinase. Their utility for measurement of MEK inhibition.
Sebolt-Leopold JS, Van Becelaere K, Hook K, Herrera R.
Sebolt-Leopold JS, et al. Among authors: van becelaere k.
Methods Mol Med. 2003;85:31-8. doi: 10.1385/1-59259-380-1:31.
Methods Mol Med. 2003.
PMID: 12710194
Review.
No abstract available.
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Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies.
Lorusso PM, Adjei AA, Varterasian M, Gadgeel S, Reid J, Mitchell DY, Hanson L, DeLuca P, Bruzek L, Piens J, Asbury P, Van Becelaere K, Herrera R, Sebolt-Leopold J, Meyer MB.
Lorusso PM, et al. Among authors: van becelaere k.
J Clin Oncol. 2005 Aug 10;23(23):5281-93. doi: 10.1200/JCO.2005.14.415. Epub 2005 Jul 11.
J Clin Oncol. 2005.
PMID: 16009947
Clinical Trial.
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Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF.
Ahn K, et al. Among authors: van becelaere k.
J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19.
J Pharmacol Exp Ther. 2011.
PMID: 21505060
Free PMC article.
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Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF.
Ahn K, et al. Among authors: van becelaere k.
Chem Biol. 2009 Apr 24;16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013.
Chem Biol. 2009.
PMID: 19389627
Free PMC article.
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Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro.
Meng XW, Chandra J, Loegering D, Van Becelaere K, Kottke TJ, Gore SD, Karp JE, Sebolt-Leopold J, Kaufmann SH.
Meng XW, et al. Among authors: van becelaere k.
J Biol Chem. 2003 Nov 21;278(47):47326-39. doi: 10.1074/jbc.M304793200. Epub 2003 Sep 8.
J Biol Chem. 2003.
PMID: 12963734
Free article.
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