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Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal Catalysis.
Arrington K, Barcan GA, Calandra NA, Erickson GA, Li L, Liu L, Nilson MG, Strambeanu II, VanGelder KF, Woodard JL, Xie S, Allen CL, Kowalski JA, Leitch DC. Arrington K, et al. Among authors: vangelder kf. J Org Chem. 2019 Apr 19;84(8):4680-4694. doi: 10.1021/acs.joc.8b02269. Epub 2018 Oct 29. J Org Chem. 2019. PMID: 30339385
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Dong S, VanGelder K, Shi ZC, Yu Y, Wu Z, Ferguson R, Guo ZZ, Tang H, Frie J, Fu Q, Gu X, Priest BT, Thomas-Fowlkes B, Weinglass A, Margulis M, Liu J, Pai LY, Hampton C, Haimbach RE, Owens K, Tong V, Xu S, Hu M, Zingaro GJ, Morissette P, Ehrhart J, Roy S, Sullivan K, Pasternak A. Dong S, et al. Among authors: vangelder k. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566. doi: 10.1016/j.bmcl.2017.03.086. Epub 2017 Mar 30. Bioorg Med Chem Lett. 2017. PMID: 28431879
Palladium-Catalyzed α-Arylation of Aryl Nitromethanes.
VanGelder KF, Kozlowski MC. VanGelder KF, et al. Org Lett. 2015 Dec 4;17(23):5748-51. doi: 10.1021/acs.orglett.5b02793. Epub 2015 Nov 20. Org Lett. 2015. PMID: 26584680 Free PMC article.