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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.
Belan O, Sebald M, Adamowicz M, Anand R, Vancevska A, Neves J, Grinkevich V, Hewitt G, Segura-Bayona S, Bellelli R, Robinson HMR, Higgins GS, Smith GCM, West SC, Rueda DS, Boulton SJ. Belan O, et al. Among authors: vancevska a. Mol Cell. 2022 Dec 15;82(24):4664-4680.e9. doi: 10.1016/j.molcel.2022.11.008. Epub 2022 Nov 30. Mol Cell. 2022. PMID: 36455556 Free article.
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.
Anand R, Buechelmaier E, Belan O, Newton M, Vancevska A, Kaczmarczyk A, Takaki T, Rueda DS, Powell SN, Boulton SJ. Anand R, et al. Among authors: vancevska a. Nature. 2022 Jan;601(7892):268-273. doi: 10.1038/s41586-021-04261-0. Epub 2021 Dec 22. Nature. 2022. PMID: 34937945 Free PMC article.
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, Schneider-Luftman D, Herbert E, Stamp G, Brough R, Pettitt S, Lord CJ, West SC, Ahel I, Ahel D, Chapman JR, Deindl S, Boulton SJ. Hewitt G, et al. Among authors: vancevska a. Mol Cell. 2021 Feb 18;81(4):767-783.e11. doi: 10.1016/j.molcel.2020.12.006. Epub 2020 Dec 16. Mol Cell. 2021. PMID: 33333017 Free PMC article.
The human telomeric proteome during telomere replication.
Lin CG, Näger AC, Lunardi T, Vančevska A, Lossaint G, Lingner J. Lin CG, et al. Among authors: vancevska a. Nucleic Acids Res. 2021 Dec 2;49(21):12119-12135. doi: 10.1093/nar/gkab1015. Nucleic Acids Res. 2021. PMID: 34747482 Free PMC article.