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The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.
Gonzalez Malagon SG, Melidoni AN, Hernandez D, Omar BA, Houseman L, Veeravalli S, Scott F, Varshavi D, Everett J, Tsuchiya Y, Timms JF, Phillips IR, Shephard EA. Gonzalez Malagon SG, et al. Among authors: veeravalli s. Biochem Pharmacol. 2015 Aug 1;96(3):267-77. doi: 10.1016/j.bcp.2015.05.013. Epub 2015 Jun 4. Biochem Pharmacol. 2015. PMID: 26049045 Free PMC article.
Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism.
Phillips IR, Veeravalli S, Khadayate S, Shephard EA. Phillips IR, et al. Among authors: veeravalli s. PLoS One. 2023 Jun 2;18(6):e0286692. doi: 10.1371/journal.pone.0286692. eCollection 2023. PLoS One. 2023. PMID: 37267233 Free PMC article.
24 results