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Development of an mRNA replacement therapy for phenylketonuria.
Perez-Garcia CG, Diaz-Trelles R, Vega JB, Bao Y, Sablad M, Limphong P, Chikamatsu S, Yu H, Taylor W, Karmali PP, Tachikawa K, Chivukula P. Perez-Garcia CG, et al. Among authors: vega jb. Mol Ther Nucleic Acids. 2022 Feb 28;28:87-98. doi: 10.1016/j.omtn.2022.02.020. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35356682 Free PMC article.
Systemic delivery of factor IX messenger RNA for protein replacement therapy.
Ramaswamy S, Tonnu N, Tachikawa K, Limphong P, Vega JB, Karmali PP, Chivukula P, Verma IM. Ramaswamy S, et al. Among authors: vega jb. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1941-E1950. doi: 10.1073/pnas.1619653114. Epub 2017 Feb 15. Proc Natl Acad Sci U S A. 2017. PMID: 28202722 Free PMC article.
Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models.
Perley CC, Brocato RL, Wu H, Bausch C, Karmali PP, Vega JB, Cohen MV, Somerville B, Kwilas SA, Principe LM, Shamblin J, Chivukula P, Sullivan E, Hooper JW. Perley CC, et al. Among authors: vega jb. Front Microbiol. 2020 May 7;11:832. doi: 10.3389/fmicb.2020.00832. eCollection 2020. Front Microbiol. 2020. PMID: 32508764 Free PMC article.
CD8+ T cells mediate protection against Zika virus induced by an NS3-based vaccine.
Elong Ngono A, Syed T, Nguyen AV, Regla-Nava JA, Susantono M, Spasova D, Aguilar A, West M, Sparks J, Gonzalez A, Branche E, DeHart JL, Vega JB, Karmali PP, Chivukula P, Kamrud K, Aliahmad P, Wang N, Shresta S. Elong Ngono A, et al. Among authors: vega jb. Sci Adv. 2020 Nov 4;6(45):eabb2154. doi: 10.1126/sciadv.abb2154. Print 2020 Nov. Sci Adv. 2020. PMID: 33148638 Free PMC article.
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.
de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE. de Alwis R, et al. Mol Ther. 2021 Jun 2;29(6):1970-1983. doi: 10.1016/j.ymthe.2021.04.001. Epub 2021 Apr 5. Mol Ther. 2021. PMID: 33823303 Free PMC article.
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.
Diaz-Trelles R, Lee S, Kuakini K, Park J, Dukanovic A, Gonzalez JA, Dam T, Kim JH, Vega JB, Sablad M, Karmali PP, Tachikawa K, Chivukula P. Diaz-Trelles R, et al. Among authors: vega jb. Mol Genet Metab Rep. 2022 May 14;32:100882. doi: 10.1016/j.ymgmr.2022.100882. eCollection 2022 Sep. Mol Genet Metab Rep. 2022. PMID: 35600090 Free PMC article.
A truncated HIV Tat demonstrates potent and specific latency reversal activity.
Van Gulck E, Pardons M, Nijs E, Verheyen N, Dockx K, Van Den Eynde C, Battivelli E, Vega J, Florence E, Autran B, Archin NM, Margolis DM, Katlama C, Hamimi C, Van Den Wyngaert I, Eyassu F, Vandekerckhove L, Boden D. Van Gulck E, et al. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0041723. doi: 10.1128/aac.00417-23. Epub 2023 Oct 24. Antimicrob Agents Chemother. 2023. PMID: 37874295 Free PMC article.
13 results